Handbook of Developmental Neurotoxicology (eBook)

Louis W. Chang, William Slikker Jr. (Autoren)

eBook Download: PDF

1998 | 1. Auflage
748 Seiten
Elsevier Science (Verlag)
978-0-08-053343-8 (ISBN)

Infos

The Handbook of Developmental Neurotoxicology provides a comprehensive account of the impacts, mechanisms, and clinical relevances of chemicals on the development of the nervous system. The book is written by internationally recognized experts on developmental neurotoxicology, covering subjects from basic neuro-development to toxic syndromes induced by various chemicals. It is an important text for both students and professionals who are interested in developmental neurobiology and neurotoxicology.

Key Features
* Written by internationally recognized experts on developmental neurotoxicology
* Includes extensive references
* Well illustrated with diagrams, charts and tables
* Provides coverage of basic neurobiology as well as neurotoxicology

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The Handbook of Developmental Neurotoxicology provides a comprehensive account of the impacts, mechanisms, and clinical relevances of chemicals on the development of the nervous system. The book is written by internationally recognized experts on developmental neurotoxicology, covering subjects from basic neuro-development to toxic syndromes induced by various chemicals. It is an important text for both students and professionals who are interested in developmental neurobiology and neurotoxicology. - Written by internationally recognized experts on developmental neurotoxicology- Includes extensive references- Well illustrated with diagrams, charts and tables- Provides coverage of basic neurobiology as well as neurotoxicology

Inhalt

Front Cover 1
Handbook of Developmental Neurotoxicology 4
Copyright Page 5
Contents 8
Contributors 12
Foreword 16
Preface 18
Part I: Cellular and Molecular Morphogenesis of the Nervous System 20
Chapter 1. Brain Morphogenesis and Developmental Neurotoxicology 22
Chapter 2. Cadherin Cell Adhesion Molecules in Normal and Abnormal Neural Development 62
Chapter 3. Neurite Development 80
Chapter 4. Myelination, Dysmyelination, and Demyelination 106
Part II: Developmental Biology/Toxicology 136
Chapter 5. Signal Transduction Pathways as Targets for Induced Embryotoxicity 138
Chapter 6. Trophic Nerve Growth Factors 160
Chapter 7. Neurotoxic and Neurotrophic Effects of Gabaergic Agents on Developing Neurotransmitter Systems 172
Chapter 8. Apoptosis 178
Chapter 9. Periods of Susceptibility to Induced Malformations of the Developing Mammalian Brain 208
Chapter 10. Transgenic Animal Models: Functional Analysis of Developmental Toxicity as Illustrated With the P53 Suppressor Model 228
Part III: Synaptogenesis and Neurotransmission 242
Chapter 11. Neural Crest Cell Migration 244
Chapter 12. Ontogeny of Neurotransmitters: Monoamines 264
Chapter 13. Central Cholinergic Neurobiology 276
Chapter 14. Ontogeny of Second Messenger Systems 294
Chapter 15. The N-Methyl-D-Aspartate Receptor: Physiology and Neurotoxicology in the Developing Brain 304
Part IV: Nutrient and Chemical Disposition 324
Chapter 16. PB/PK Models 326
Chapter 17. Developmental Enzymology: Xenobiotic Biotransformation 340
Chapter 18. Blood-Brain Barrier: Physiological and Functional Considerations 358
Chapter 19. Antioxidant Enzymes: Developmental Profiles and Their Role in Metal-Induced Oxidative Stress 372
Chapter 20. Food and Nutrient Exposure Throughout the Life Span: How Does What We Eat Translate Into Exposure, Deficiencies, and Toxicities? 390
Chapter 21. Drug and Chemical Contaminants in Breast Milk: Effects on Neurodevelopment of the Nursing Infant 402
Part V: Behavioral Assessment 420
Chapter 22. Behavioral Assessment in Developmental Neurotoxicology: Approaches Involving Unconditioned Behaviors and Pharmacologic Challenges in Rodents 422
Chapter 23. Assessment of Behavior in Primates 446
Part VI: Clinical Assessment and Epidemiology 456
Chapter 24. Evaluation of the Human Newborn Infant 458
Chapter 25. Developmental Evaluation of the Older Infant and Child 474
Chapter 26. Behavioral Evaluation of the Older Infant and Child 488
Chapter 27. Epidemiologic Studies of the Effects of Prenatal Cocaine Exposure on Child Development and Behavior 506
Chapter 28. Assessment of Case Reports and Clinical Series 516
Part VII: Specific Neurotoxic Syndromes 524
Chapter 29. Fetal Minamata Disease: Congenital Methylmercury Poisoning 526
Chapter 30. Developmental Neurotoxicity of Cadmium 536
Chapter 31. Developmental Lead Exposure: Neurobehavioral Consequences 558
Chapter 32. Developmental Toxicity of Pesticides 578
Chapter 33. The Effects of Alcohol on the Fetal Brain: the Central Nervous System Tragedy 586
Chapter 34. Developmental Neurotoxicity of Nicotine 606
Chapter 35. Maternal Drug Abuse and Adverse Effects on Neurobehavior of Offspring 636
Chapter 36. The Neurobehavioral Teratology of Vitamin A Analogs 650
Chapter 37. Developmental Neurotoxicity of Antiepileptic Drugs 662
Chapter 38. Neuroteratology of Autism 680
Part VIII: Risk Assessment 692
Chapter 39. Current Approaches to Risk Assessment for Developmental Neurotoxicity 694
Chapter 40. Animal/Human Concordance 706
Chapter 41. Physiologically Based Pharmacokinetic Models in the Risk Assessment of Developmental Neurotoxicants 728
Chapter 42. Quantitative Models of Risk Assessment for Developmental Neurotoxicants 746
Index 752

Textauszug

Contributors

Numbers in parentheses indicate the pages on which the authors’ contributions begins.

AdamsJane     (631) Department of Psychology, University of Massachusetts, Boston, Massachusetts

AliSyed F.     (353) Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas

AndersenMelvin     (709) ICF Kaiser, Inc., Research Triangle Park, North Carolina

AschnerMichael     (339) Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

AudesirkGerald     (61) Department of Biology, University of Colorado, Denver, Colorado

AudesirkTeresa     (61) Department of Biology, University of Colorado, Denver, Colorado

BennettGregory D.     (189) Departments of Veterinary Anatomy and Public Health, Texas A&M University, College Station, Texas

BogleMargaret L.     (371) Delta Nutrition Intervention Research Initiative, U.S. Department of Agriculture/ARS, Little Rock, Arkansas

BroeningHarry W.     (257) Exxon Biomedical Sciences, Inc., East Millstone, New Jersey

Casaccia-BonnefilPatrizia     (141) Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York, New York

CatalanoSusan M.     (3) Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, California

ChangLouis W.     (507) Departments of Pathology, Pharmacology, and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas

ChaoMoses V.     (141) Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York, New York

ChenHao     (321) Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington

ColesClaire D.     (455) Department of Psychiatry and Behavioral Sciences, Marcus Institute at Emory University, and Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia

CostaLucio G.     (275) Department of Environmental Health, University of Washington, Seattle, Washington, and Toxicology Units, Fondazione S. Maugeri, Pavia, Italy

DayNancy L.     (487) Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

DesaiahDurisala     (559) University of Mississippi Medical Center, Jackson, Mississippi

FinnellRichard H.     (189) Departments of Veterinary Anatomy and Public Health, Texas A&M University, College Station, Texas

FriedPeter A.     (469) Department of Psychology, Carleton University, Ottawa, Ontario, Canada

FriedmanJ.M.     (497) Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

GaylorDavid W.     (727) Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas

GladstoneJonathan     (567) The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

GreeneRobert M.     (119) Department of Biological and Biophysical Sciences, University of Louisville School of Dentistry, Louisville, Kentucky

GrunwaldGerald B.     (43) Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania

GuilarteTomás R.     (285) Department of Environmental Health Sciences, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland

GuoGrace Liejun     (507) Department of Pharmacology and Toxicology, University of Kansas Medical Center, Kansas City, Kansas

HansenDeborah K.     (643) Division of Reproductive and Developmental Toxicology, Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas

HarryG. Jean     (87) National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina

HastingsLloyd     (517) Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio

HendrickxAndrew G.     (225) California Regional Primate Research Center, University of California, Davis, California

HolsonR. Robert     (631, 643) Division of Reproductive and Developmental Toxicology, Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas

HussainSaber     (353) Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas

JensenKarl F.     (3) Neurotoxicology Division, National Health and Environmental Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina

JettDavid A.     (257) Department of Environmental Health Science, Johns Hopkins University, Baltimore, Maryland

JuchauMont R.     (321) Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington

KableJulie A.     (455) Marcus Institute at Emory University, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia

KimmelCarole A.     (675) National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, DC

KnudsenThomas B.     (209) Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania

KongHaeyoung     (141) Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York, New York

KorenGideon     (567) The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, and The Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

KrishnanKannan     (709) Group of Research on Human Toxicology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada

LauderJean M.     (153) Department of Cell Biology and Anatomy, University of North Carolina School of Medicine, Chapel Hill, North Carolina

LevinEdward D.     (587) Departments of Psychiatry and Pharmacology, Duke University Medical Center, Durham, North Carolina

LiuJiangping     (153) Department of Cell Biology and Anatomy, University of North Carolina School of Medicine, Chapel Hill, North Carolina

MeyerJerrold S.     (403) Department of Psychology, Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts

MillerMarian L.     (517) Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio

MirkesPhilip E.     (159) Department of Pediatrics, University of Washington, Seattle, Washington

NugentPaul     (119) Department of Biological and Biophysical Sciences, University...

Produkt-Details

• Erscheint lt. Verlag: 10.8.1998
• Sprache: englisch
• Themenwelt: Geisteswissenschaften ► Psychologie ► Entwicklungspsychologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• ISBN-10: 0-08-053343-4 / 0080533434
• ISBN-13: 978-0-08-053343-8 / 9780080533438