Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation (eBook)

Annika B. Malmberg, Keith R. Bley (Herausgeber)

eBook Download: PDF

2006 | 2005
XII, 249 Seiten
Springer Basel (Verlag)
978-3-7643-7379-5 (ISBN)

Infos

Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized [2]. In Chapter 1 of this volume, Janos Szolcsányi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema.

Inhalt

Historical perspective on capsaicin and its receptor.- Hot peppers, pain and analgesics.- Molecular and cellular properties of vanilloid receptors.- Structural determinants of TRPV1 functionality.- TRPV1 distribution and regulation.- Pharmacology and physiology of vanilloid receptors.- Insights into TRPV1 pharmacology provided by non-capsaicin ligands.- Endocannabinoids and vanilloid TRPV1 receptors.- Vanilloid receptor-mediated hyperalgesia and desensitization.- Capsaicin in human experimental pain models of skin, muscle and visceral sensitization.- Vanilloid receptor involvement in disease states.- TRPV1 in gut function, abdominal pain and functional bowel disorders.- TRPV1 in the airways.- Therapeutic potential of vanilloid agonists and antagonists.- TRPV1 agonist-based therapies: mechanism of action and clinical prospects.- TRPV1 agonist therapies in bladder diseases.- TRPV1 antagonists and chronic pain.

Produkt-Details

• Erscheint lt. Verlag: 17.1.2006
• Reihe/Serie: Progress in Inflammation Research
• Reihe/Serie: Progress in Inflammation Research
• Zusatzinfo: XII, 249 p.
• Verlagsort: Basel
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Activation • analgesia • Analgesics • Bladder diseases • Cannabinoid • Capsaicin • Cation channel • Diseases • Drug • drug development • inflammation • lead • Muscle • neurons • Neuropathic pain • Pain • pharmacology • Physiology • Regulation • Therapeutic potential • Treatment • TRPV1
• ISBN-10: 3-7643-7379-2 / 3764373792
• ISBN-13: 978-3-7643-7379-5 / 9783764373795