Basic Biology and Clinical Impact of Immunosenescence (eBook)

G. Pawelec (Autor)

eBook Download: PDF

2003 | 1. Auflage
322 Seiten
Elsevier Science (Verlag)
978-0-08-054648-3 (ISBN)

Infos

Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved successful ageing (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.

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Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved "e;successful ageing"e; (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.

Inhalt

Cover 1
Table of Contents 6
Preface 8
Chapter 1. The OCTO and NONA Immune Longitudinal Studies: A Review of 11 years Studies of Swedish very old humans 12
Chapter 2. Immune Measures which Predict 9-Year Survival in an Elderly Population Sample 28
Chapter 3. Immunological and Immunogenetic Markers of Successful and Unsuccessful Ageing 40
Chapter 4. Developmental Aspects of the Thymus in Aging 58
Chapter 5. Effective Immunity During Late Life A Possible Role for the Thymus
Chapter 6. Alterations in Signal Transduction in T Lymphocytes and Neutrophils with Ageing 104
Chapter 7. CD28 Downregulation and Expression of NK-Associated Receptors on T Cells in Aging and Situations of Chronic Activation of the Immune System 134
Chapter 8. Characterisation of NK Cells in the Elderly 144
Chapter 9. T Cell Ageing and Immune Surveillance 170
Chapter 10. A Road to Ruins: An Insight Into Immunosenescence 184
Chapter 11. Genetic Damage and Ageing T Cells 202
Chapter 12. Role of DNA-dependent Protein Kinase (DNA-PK), A Protein with Multiple Intracellular Functions, in Cells of the Ageing Immune System 228
Chapter 13. Linker Histone H1o Gene Expression During Ageing and After the Effect of Histone Deacetylase Inhibitors in Human Diploid Fibroblasts and T Lymphocytes 242
Chapter 14. Zinc and the Immune System of Elderly 254
Chapter 15. Altered Zinc Binding by Metallothioneins in Immune-Neuroendocrine Senescence: A Vicious Circle Between Metallothioneins and Chaperones? 272
Chapter 16. T Cell Exhaustion and Aging: Is Replicative Senescence Relevant? 294
Chapter 17. Cultured T cell Clones as Models for Immunosenescence 306
Contributor Addresses 320

Produkt-Details

• Erscheint lt. Verlag: 1.5.2003
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• ISBN-10: 0-08-054648-X / 008054648X
• ISBN-13: 978-0-08-054648-3 / 9780080546483