Progress in Nucleic Acid Research and Molecular Biology (eBook)

Kivie Moldave (Herausgeber)

eBook Download: PDF

2003 | 1. Auflage
292 Seiten
Elsevier Science (Verlag)
978-0-08-049786-0 (ISBN)

Infos

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.

* Provides a forum for discussion of new discoveries, approaches and ideas in molecular biology
* Includes contributions from the leaders in the field
* Has abundant references

Inhalt

Cover 1
Contents 6
Some Articles Planned for Future Volumes 10
Chapter 1. T7 RNA Polymerase 12
I. Introduction 13
II. Structure and Structure-Function Relationships 13
III. Sequence and Structural Similarities, Phylogeny, and Origins 22
IV. The Transcription Reaction 24
V. Regulation 40
VI. DNA Replication 43
VII. T7 RNAP„Applications 44
References 46
Chapter 2. DNA Supercoiling and Transcription Control: A Model from the Study of Suppression of the leu-500 Mutation in Salmonella typhimurium topA– Strains 54
DNA Supercoiling and Gene Expression Regulation 55
II. Suppression of leu-500 Mutation in Salmonella typhimurium topA Mutants: An Old Phenomenon Revisited 59
III. A New Explanation for the Old Phenomenon, the Suppression of leu-500 Mutation in Salmonella typhimurium topA– Mutants 65
IV. The Promoter Relay in the ilvIH–leuO–leuABCD Gene Cluster Is a Bacterial Stress Response 67
V. Conlcuding Remarks 72
VI. Perspective 73
References 74
Chapter 3. Protein Tyrosyl Phosphatases in T Cell Activation: Implication for Human Immunodeficiency Virus Transcriptional Activity 80
I. Structure and Function of Protein Tyrosine Phosphatases in T Cells 81
II. Regulation of HIV-1 Replication by PTPs 95
III. Conclusions and Perspectives 107
References 108
Chapter 4. Dynamic Interplay between O-Glycosylation and O-Phosphorylation of Nucleocytoplasmic Proteins: A New Paradigm for Metabolic Control of Signal Transduction and Transcription 118
I. Dynamic Interplay between O-Glycosylation and O-Phosphorylation of Nucleocytoplasmic Proteins 119
II. Future Directions 137
References 138
Chapter 5. Fidelity Mechanisms of DNA Polymerase B 148
I. Introduction 149
II. The DNA Polymerase Reaction Mechanism 150
III. DNA Polymerases Function in Nucleotide Selectivity 151
IV. Inherent Characteristics of Error Production by DNA Polymerase B 152
V. Overview of DNA Polymerase B Fidelity Mechanisms 153
VI. Nucleotide Selectivity during Binding of the Nucleotide Substrate to Pol B 155
VII. Nucleotide Selectivity during Phosphodiester Bond Formation 163
VIII. Precise Positioning of DNA Is Important for Fidelity 169
IX. Positioning of Active Site Residues Is Critical for Fidelity 173
X. Perspectives and Concluding Remarks 175
References 176
Chapter 6. Mechanistic Studies of Protein Tyrosine Phosphatases 182
I. Classification of the PTP Superfamily 184
II. Functional Roles of PTPs in Cellular Signaling 188
III. Structural Features of PTPs 189
IV. Mechanistic Studies of the PTP-Catalyzed Reaction 193
V. A Conserved Mechanism for PTP Satalysis 209
VI. The Nature of the Transition State of the Phosphate Monoester Hydrolysis 210
VII. Concluding Remarks and Future Perspectives 220
References 221
Chapter 7. The CCR4–NOT Complex Plays Diverse Roles in mRNA Metabolism 232
I. Introduction 233
II. The CCR4–NOT Complexes and Their Constituents 233
III. Roles of the CCR4–NOT Complex in mRNA Metabolism 245
IV. CCR4–NOT Roles in Integrating Cell Signaling Pathways 252
V. Perspective 254
References 256
Chapter 8. Transcriptional Control of Multidrug Resistance in the Yeast Saccharomyces 262
I. Introduction 262
II. Positive Transcriptional Regulators 264
III. Negative Regulators 274
IV. Conclusions 280
References 282
Index 292

Produkt-Details

• Erscheint lt. Verlag: 15.9.2003
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• ISBN-10: 0-08-049786-1 / 0080497861
• ISBN-13: 978-0-08-049786-0 / 9780080497860