Arsenic Exposure and Health Effects III (eBook)
416 Seiten
Elsevier Science (Verlag)
978-0-08-052757-4 (ISBN)
While developed countries are considering spending perhaps billions of dollars per year to reach concentrations of 10 micrograms per liter or less, countries like Bangladesh, India and China are trying to deal with much more severe, epidemic scale, arsenic problems with millions of dollars or less.
Like its predecessors in 1994 and 1995, The Third SEGH International Conference on Arsenic Exposure and Health Effects (1998) continued the theme of global impact of arsenic. In addition, two new countries with significant arsenic problems, Inner Mongolia and Bangladesh, were represented. The Bangladesh problem could be larger than the one in West Bengal with a possible two-thirds of the population at risk. The conference also featured a session on mechanisms of cancer carcinogenesis. Several scientists presented their work on this important issue which is central to considerations of such questions as the shape of the dose-response curve at low doses. This latter issue was featured in the final session of the conference. Another session that was new and of great interest was on the treatment of victims of chronic arsenic poisoning.
This was the most dynamic conference to date and this resulting monograph represents the state-of-the-art in arsenic research on a worldwide basis. It will contribute to the solution of the many problems caused by arsenic exposure throughout the world.
The Society of Environmental Geochemistry and Health (SEGH) Third International Conference on Arsenic Exposure and Health Effects was held from July 12-15, 1998 in San Diego, California. Several outstanding papers and posters generated lively discussion and debate not only about scientific issues but also about policy and regulatory issues. While developed countries are considering spending perhaps billions of dollars per year to reach concentrations of 10 micrograms per liter or less, countries like Bangladesh, India and China are trying to deal with much more severe, epidemic scale, arsenic problems with millions of dollars or less. Like its predecessors in 1994 and 1995, The Third SEGH International Conference on Arsenic Exposure and Health Effects (1998) continued the theme of global impact of arsenic. In addition, two new countries with significant arsenic problems, Inner Mongolia and Bangladesh, were represented. The Bangladesh problem could be larger than the one in West Bengal with a possible two-thirds of the population at risk. The conference also featured a session on mechanisms of cancer carcinogenesis. Several scientists presented their work on this important issue which is central to considerations of such questions as the shape of the dose-response curve at low doses. This latter issue was featured in the final session of the conference. Another session that was new and of great interest was on the treatment of victims of chronic arsenic poisoning. This was the most dynamic conference to date and this resulting monograph represents the state-of-the-art in arsenic research on a worldwide basis. It will contribute to the solution of the many problems caused by arsenic exposure throughout the world.
Cover
1
Contents 10
Dedication 6
Preface 8
List of Contributors 14
PART I: OCCURRENCE AND EXPOSURE 22
Chapter 1. Arsenic in the Global Environment: Looking Towards the Millenium 22
Chapter 2. Arsenic in Ground Water Supplies of the United States 30
Chapter 3. Airborne Exposure to Arsenic Occurring in Coal Fly Ash 40
Chapter 4. Consistency of Biomarkers of Exposure to Inorganic Arsenic: Review of Recent Data 52
Chapter 5. Hair Arsenic as an Index of Toxicity 62
PART II: FOOD AND OTHER EXPOSURE MEDIA 72
Chapter 6. Estimating Total Arsenic Exposure in the United States 72
Chapter 7. Arsenic Compounds in Terrestrial Biota 82
Chapter 8. Exposure to Arsenosugars from Seafood Ingestion and Speciation of Urinary Arsenic Metabolites 90
Chapter 9. Dietary Exposure to Inorganic Arsenic 102
Chapter 10. Exposure to Inorganic Arsenic from Fish and Shellfish 110
PART III: GENERAL OVERVIEW OF ARSENIC RISK 120
Chapter 11. Application of the Risk Assessment Approaches in the USEPA Proposed Cancer Guidelines to Inorganic Arsenic 120
Chapter 12. Emerging Epidemics of Arseniasis in Asia 134
PART IV: HEALTH EFFECTS„NON-CANCER 144
Chapter 13. The Present Situation of Chronic Arsenism and Research in China 144
Chapter 14. Human Exposure to Arsenic and Health Effects in Bayingnormen, Inner Mongolia 148
Chapter 15. Drinking Water Arsenic: The Millard County, Utah Mortality Study 154
Chapter 16. Association between Chronic Arsenic Exposure and Children's Intelligence in Thailand 162
Chapter 17. Reproductive and Developmental Effects Associated with Chronic Arsenic Exposure 172
Chapter 18. Groundwater Arsenic Contamination and Suffering of People in Bangladesh 186
Chapter 19. Inorganic Arsenic and Prenatal Development: A Comprehensive Evaluation for Human Risk Assessment 204
PART V: HEALTH EFFECTS„CANCER 212
Chapter 20. Cancer Risks from Arsenic in Drinking Water: Implications for Drinking Water Standards 212
Chapter 21. Preliminary Incidence Analysis in Skin Basalioma Patients Exposed to Arsenic in Environmental and Occupational Settings 222
Chapter 22. Model Sensitivity in an Analysis of Arsenic Exposure and Bladder Cancer in Southwestern Taiwan 228
Chapter 23. Tumours in Mice Induced by Exposure to Sodium Arsenate in Drinking Water 238
Chapter 24. Subchronic Toxicity Study of Sodium Arsenite in Methyl-Deficient Male C57BL/6 Mice 246
PART VI: MECHANISMS 254
Chapter 25. Arsenite Genotoxicity May Be Mediated by Interference with DNA Damage-inducible Signaling 254
Chapter 26. Modulation of DNA Repair and Glutathione Levels in Human Keratinocytes by Micromolar Arsenite 264
Chapter 27. Evaluation of Cell Proliferative Activity in the Rat Urinary Bladder After Feeding High Doses of Cacodylic Acid 274
Chapter 28. Differences of Promoting Activity and Loss of Heterozygosity Between Dimethylarsinic Acid and Sodium L-ascorbate in F1 Rat Urinary Bladder Carcinogenesis 284
PART VII: METABOLISM 288
Chapter 29. Variation in Human Metabolism of Arsenic 288
Chapter 30. Profile of Urinary Arsenic Metabolites in Children Chronically Exposed to Inorganic Arsenic in Mexico 302
Chapter 31. How Is Inorganic Arsenic Detoxified? 310
Chapter 32. Arsenic Metabolism After Pulmonary Exposure 320
Chapter 33. Metabolism and Toxicity of Arsenicals in Cultured Cells 332
Chapter 34. Proportions of Arsenic Species in Human Urine 346
PART VIII: INTERVENTIONS AND TREATMENT 356
Chapter 35. Chronic Arsenic Toxicity: Epidemiology, Natural History and Treatment 356
Chapter 36. Clinical Approaches to the Treatment of Chronic Arsenic Intoxication: From Chelation to Chemoprevention 370
Chapter 37. Major Interventions on Chronic Arsenic Poisoning in Ronpibool District, Thailand„ Review and Long-Term Follow Up 376
Chapter 38. Rapid Action Programme: Emergency Arsenic Mitigation Programme in Two Hundred Villages in Bangladesh 384
Chapter 39. Public Health Hazard Surveillance and Response to Arsenic Contamination 388
PART IX: TREATMENT AND REMEDIATION 394
Chapter 40. Full-scale Application of Coagulation Processes for Arsenic Removal in Chile: A Successful Case Study 394
Chapter 41. Development of an Anion Exchange Process for Arsenic Removal from Water 400
Chapter 42. Subterranean Removal of Arsenic from Groundwater 410
PART X: DOSE RESPONSE 418
Chapter 43. Mode of Action Studies for Assessing Carcinogenic Risks Posed by Inorganic Arsenic 418
Chapter 44. Observations on Arsenic Exposure and Health Effects 428
Keyword Index 436
| Erscheint lt. Verlag | 6.12.1999 |
|---|---|
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Arbeits- / Sozial- / Umweltmedizin |
| Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie | |
| Naturwissenschaften ► Biologie ► Ökologie / Naturschutz | |
| Technik ► Umwelttechnik / Biotechnologie | |
| ISBN-10 | 0-08-052757-4 / 0080527574 |
| ISBN-13 | 978-0-08-052757-4 / 9780080527574 |
| Haben Sie eine Frage zum Produkt? |
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