Power Laws, Scale-Free Networks and Genome Biology (eBook)
XVI, 258 Seiten
Springer US (Verlag)
978-0-387-33916-0 (ISBN)
Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era. The chapters in the book not only describe the interesting mathematical properties of biological networks but moves beyond phenomenology, toward models of evolution capable of explaining the emergence of these features. The collection of chapters, contributed by both physicists and biologists, strives to address the problems in this field in a rigorous but not excessively mathematical manner and to represent different viewpoints, which is crucial in this emerging discipline. Each chapter includes, in addition to technical descriptions of properties of biological networks and evolutionary models, a more general and accessible introduction to the respective problems. Most chapters emphasize the potential of theoretical systems biology for discovery of new biological phenomena.
Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era. The chapters in the book not only describe the interesting mathematical properties of biological networks but moves beyond phenomenology, toward models of evolution capable of explaining the emergence of these features. The collection of chapters, contributed by both physicists and biologists, strives to address the problems in this field in a rigorous but not excessively mathematical manner and to represent different viewpoints, which is crucial in this emerging discipline. Each chapter includes, in addition to technical descriptions of properties of biological networks and evolutionary models, a more general and accessible introduction to the respective problems. Most chapters emphasize the potential of theoretical systems biology for discovery of new biological phenomena.
CONTENTS 5
EDITORS 9
CONTRIBUTORS 9
Power Laws in Biological Networks 19
Graphical Analysis of Biocomplex Networks and Transport Phenomena 30
Large- Scale Topological Properties of Molecular Networks 43
The Connectivity of Large Genetic Networks 58
The Drosophila Protein Interaction Network May Be neither Power- Law nor Scale- Free 71
Birth and Death Models of Genome Evolution 83
Scale- Free Evolution 104
Gene Regulatory Networks 124
Power Law Correlations in DNA Sequences 141
Analytical Evolutionary Model for Protein Fold Occurrence in Genomes, Accounting for the Effects of Gene Duplication, Deletion, Acquisition and Selective Pressure 183
The Protein Universes 212
The Role of Computation in Complex Regulatory Networks 224
Neutrality and Selection in the Evolution of Gene Families 244
Scaling laws in the Functional Content of Genomes 254
Index 272
| Erscheint lt. Verlag | 6.3.2007 |
|---|---|
| Reihe/Serie | Molecular Biology Intelligence Unit | Molecular Biology Intelligence Unit |
| Zusatzinfo | XVI, 258 p. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik | |
| Technik | |
| Schlagworte | DNA • Evolution • genes • Genetics • Genome • Mathematical Modeling • Molecular Biology • Protein • Proteomics • Regulation • transcription |
| ISBN-10 | 0-387-33916-7 / 0387339167 |
| ISBN-13 | 978-0-387-33916-0 / 9780387339160 |
| Haben Sie eine Frage zum Produkt? |
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