Transforming Growth Factor-Beta in Cancer Therapy, Volume II (eBook)

Cancer Treatment and Therapy

Sonia B. Jakowlew (Herausgeber)

eBook Download: PDF

2010 | 2008
XXVI, 786 Seiten
Humana Press (Verlag)
978-1-59745-293-9 (ISBN)

Infos

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts.

The companion volume details the role of TGF- ß on basic and clinical biology.

---

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim- ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.

Inhalt

0003 1
0004 2
0005 3
0006 4
0007 5
0008 6
0009 7
0010 8
0011 9
0012 10
0013 11
0015 12
0017 13
0018 14
0019 15
0020 16
0021 17
0022 18
0023 19
0024 20
0025 21
0026 22
0027 23
0028 24
0029 25
0031 26
0032 27
0033 28
0034 29
0035 30
0036 31
0037 32
0038 33
0039 34
0040 35
0041 36
0042 37
0043 38
0044 39
0045 40
0046 41
0047 42
0049 43
0050 44
0051 45
0052 46
0053 47
0054 48
0055 49
0056 50
0057 51
0058 52
0059 53
0060 54
0061 55
0062 56
0063 57
0064 58
0065 59
0066 60
0067 61
0068 62
0069 63
0070 64
0071 65
0072 66
0073 67
0074 68
0075 69
0076 70
0077 71
0079 72
0080 73
0081 74
0082 75
0083 76
0084 77
0085 78
0086 79
0087 80
0088 81
0089 82
0090 83
0091 84
0092 85
0093 86
0094 87
0095 88
0096 89
0097 90
0098 91
0099 92
0100 93
0101 94
0102 95
0103 96
0104 97
0105 98
0106 99
0107 100
0108 101
0109 102
0110 103
0111 104
0112 105
0113 106
0114 107
0115 108
0116 109
0117 110
0118 111
0119 112
0120 113
0121 114
0123 115
0124 116
0125 117
0126 118
0127 119
0128 120
0129 121
0130 122
0131 123
0132 124
0133 125
0134 126
0135 127
0136 128
0137 129
0138 130
0139 131
0140 132
0141 133
0142 134
0143 135
0144 136
0145 137
0146 138
0147 139
0148 140
0149 141
0150 142
0151 143
0153 144
0154 145
0155 146
0156 147
0157 148
0158 149
0159 150
0160 151
0161 152
0162 153
0163 154
0164 155
0165 156
0166 157
0167 158
0168 159
0169 160
0170 161
0171 162
0172 163
0173 164
0174 165
0175 166
0176 167
0177 168
0178 169
0179 170
0181 171
0182 172
0183 173
0184 174
0185 175
0186 176
0187 177
0188 178
0189 179
0190 180
0191 181
0192 182
0193 183
0194 184
0195 185
0196 186
0197 187
0198 188
0199 189
0200 190
0201 191
0202 192
0203 193
0204 194
0205 195
0206 196
0207 197
0209 198
0210 199
0211 200
0212 201
0213 202
0214 203
0215 204
0216 205
0217 206
0218 207
0219 208
0220 209
0221 210
0222 211
0223 212
0224 213
0225 214
0226 215
0227 216
0228 217
0229 218
0230 219
0231 220
0232 221
0233 222
0234 223
0235 224
0236 225
0237 226
0238 227
0239 228
0240 229
0241 230
0242 231
0243 232
0244 233
0245 234
0246 235
0247 236
0248 237
0249 238
0250 239
0251 240
0252 241
0253 242
0254 243
0255 244
0257 245
0258 246
0259 247
0260 248
0261 249
0262 250
0263 251
0264 252
0265 253
0266 254
0267 255
0268 256
0269 257
0270 258
0271 259
0272 260
0273 261
0274 262
0275 263
0276 264
0277 265
0278 266
0279 267
0280 268
0281 269
0282 270
0283 271
0284 272
0285 273
0286 274
0287 275
0288 276
0289 277
0291 278
0293 279
0294 280
0295 281
0296 282
0297 283
0298 284
0299 285
0300 286
0301 287
0302 288
0303 289
0304 290
0305 291
0306 292
0307 293
0308 294
0309 295
0310 296
0311 297
0312 298
0313 299
0314 300
0315 301
0316 302
0317 303
0318 304
0319 305
0320 306
0321 307
0322 308
0323 309
0324 310
0325 311
0326 312
0327 313
0328 314
0329 315
0330 316
0331 317
0332 318
0333 319
0334 320
0335 321
0337 322
0338 323
0339 324
0340 325
0341 326
0342 327
0343 328
0344 329
0345 330
0346 331
0347 332
0348 333
0349 334
0350 335
0351 336
0352 337
0353 338
0354 339
0355 340
0356 341
0357 342
0358 343
0359 344
0360 345
0361 346
0363 347
0364 348
0365 349
0366 350
0367 351
0368 352
0369 353
0370 354
0371 355
0372 356
0373 357
0374 358
0375 359
0376 360
0377 361
0378 362
0379 363
0381 364
0382 365
0383 366
0384 367
0385 368
0386 369
0387 370
0388 371
0389 372
0390 373
0391 374
0392 375
0393 376
0394 377
0395 378
0396 379
0397 380
0398 381
0399 382
0400 383
0401 384
0402 385
0403 386
0404 387
0405 388
0406 389
0407 390
0408 391
0409 392
0411 393
0412 394
0413 395
0414 396
0415 397
0416 398
0417 399
0418 400
0419 401
0420 402
0421 403
0422 404
0423 405
0424 406
0425 407
0426 408
0427 409
0428 410
0429 411
0430 412
0431 413
0432 414
0433 415
0434 416
0435 417
0436 418
0437 419
0438 420
0439 421
0440 422
0441 423
0442 424
0443 425
0445 426
0446 427
0447 428
0448 429
0449 430
0450 431
0451 432
0452 433
0453 434
0454 435
0455 436
0456 437
0457 438
0458 439
0459 440
0460 441
0461 442
0462 443
0463 444
0464 445
0465 446
0466 447
0467 448
0468 449
0469 450
0471 451
0472 452
0473 453
0474 454
0475 455
0476 456
0477 457
0478 458
0479 459
0480 460
0481 461
0482 462
0483 463
0484 464
0485 465
0486 466
0487 467
0488 468
0489 469
0491 470
0492 471
0493 472
0494 473
0495 474
0496 475
0497 476
0498 477
0499 478
0500 479
0501 480
0502 481
0503 482
0504 483
0505 484
0506 485
0507 486
0508 487
0509 488
0510 489
0511 490
0512 491
0513 492
0514 493
0515 494
0516 495
0517 496
0518 497
0519 498
0520 499
0521 500
0522 501
0523 502
0524 503
0525 504
0526 505
0527 506
0528 507
0529 508
0530 509
0531 510
0532 511
0533 512
0535 513
0536 514
0537 515
0538 516
0539 517
0540 518
0541 519
0542 520
0543 521
0544 522
0545 523
0546 524
0547 525
0548 526
0549 527
0551 528
0552 529
0553 530
0554 531
0555 532
0556 533
0557 534
0558 535
0559 536
0560 537
0561 538
0562 539
0563 540
0565 541
0566 542
0567 543
0568 544
0569 545
0570 546
0571 547
0572 548
0573 549
0574 550
0575 551
0576 552
0577 553
0578 554
0579 555
0581 556
0582 557
0583 558
0584 559
0585 560
0586 561
0587 562
0588 563
0589 564
0590 565
0591 566
0592 567
0593 568
0594 569
0595 570
0596 571
0597 572
0598 573
0599 574
0601 575
0602 576
0603 577
0604 578
0605 579
0606 580
0607 581
0608 582
0609 583
0610 584
0611 585
0612 586
0613 587
0614 588
0615 589
0617 590
0618 591
0619 592
0620 593
0621 594
0622 595
0623 596
0624 597
0625 598
0626 599
0627 600
0628 601
0629 602
0630 603
0631 604
0632 605
0633 606
0634 607
0635 608
0636 609
0637 610
0638 611
0639 612
0640 613
0641 614
0642 615
0643 616
0644 617
0645 618
0646 619
0647 620
0648 621
0649 622
0650 623
0651 624
0652 625
0653 626
0654 627
0655 628
0656 629
0657 630
0658 631
0659 632
0660 633
0661 634
0662 635
0663 636
0664 637
0665 638
0666 639
0667 640
0668 641
0669 642
0670 643
0671 644
0672 645
0673 646
0674 647
0675 648
0676 649
0677 650
0678 651
0679 652
0681 653
0682 654
0683 655
0684 656
0685 657
0686 658
0687 659
0688 660
0689 661
0690 662
0691 663
0692 664
0693 665
0694 666
0695 667
0696 668
0697 669
0699 670
0700 671
0701 672
0702 673
0703 674
0704 675
0705 676
0706 677
0707 678
0708 679
0709 680
0710 681
0711 682
0712 683
0713 684
0714 685
0715 686
0716 687
0717 688
0718 689
0719 690
0720 691
0721 692
0722 693
0723 694
0724 695
0725 696
0726 697
0727 698
0728 699
0729 700
0730 701
0731 702
0732 703
0733 704
0734 705
0735 706
0736 707
0737 708
0738 709
0739 710
0740 711
0741 712
0742 713
0743 714
0744 715
0745 716
0746 717
0747 718
0748 719
0749 720
0750 721
0751 722
0752 723
0753 724
0754 725
0755 726
0756 727
0757 728
0758 729
0759 730
0760 731
0761 732
0762 733
0763 734
0765 735
0766 736
0767 737
0768 738
0769 739
0770 740
0771 741
0772 742
0773 743
0774 744
0775 745
0776 746
0777 747
0778 748
0779 749
0780 750
0781 751
0782 752
0783 753
0784 754
0785 755
0786 756
0787 757
0788 758
0789 759
0790 760
0791 761
0792 762
0793 763
0794 764
0795 765
0796 766
0797 767
0798 768
0799 769
0800 770
0801 771
0802 772
0803 773
0804 774
0805 775
0806 776
0807 777
0808 778
0809 779
0810 780
0811 781
0812 782
0813 783
0814 784
Untitled 687

Produkt-Details

• Erscheint lt. Verlag: 1.1.2010
• Reihe/Serie: Cancer Drug Discovery and Development
• Reihe/Serie: Cancer Drug Discovery and Development
• Vorwort: C.-H. Heldin
• Zusatzinfo: XXVI, 786 p. 164 illus., 4 illus. in color.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Activation • angiogenesis • carcinoma • DNA • Endoplasmatisches Reticulum • genes • gene transfer • Leukocytes • Positron Emission Tomography • Regulation • tissue • Translation • tumor growth • Tumorigenesis • Vivo
• ISBN-10: 1-59745-293-9 / 1597452939
• ISBN-13: 978-1-59745-293-9 / 9781597452939