Metabolic Basis of Obesity (eBook)

Rexford S. Ahima (Herausgeber)

eBook Download: PDF

2010 | 2011
XIV, 391 Seiten
Springer New York (Verlag)
978-1-4419-1607-5 (ISBN)

Infos

The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.

Inhalt

Preface 8
Contents 10
Contributors 12
Principles of Human Energy Metabolism 16
Intermediary Metabolism of Carbohydrate, Protein, and Fat 39
Adipose Tissue Development, Structure and Function 66
Adipokines in Health and Disease 82
Neural Control of Feeding and Energy Homeostasis 102
Gastrointestinal Hormones and Obesity 121
Genes and Human Obesity 138
Classical Hormones Linked to Obesity 150
Inflammation and Adipose Dysfunction 166
Insulin Resistance in the Metabolic Syndrome 185
Pancreatic Islet b- Cell Failure in Obesity 209
Non-Alcoholic Fatty Liver Disease and the Metabolic Syndrome 228
Sleep, Circadian Rhythms and Metabolism 237
Obesity and Cardiac Dysfunction 264
Atherogenic Lipid Metabolism in Obesity 300
Gut Microbes, Immunity, and Metabolism 317
Impact of Obesity on Female Reproductive Health 337
Lessons from HIV Lipodystrophy and Drug- Induced Metabolic Dysfunction 348
Principles of Obesity Therapy 364
Index 385

Produkt-Details

• Erscheint lt. Verlag: 16.11.2010
• Zusatzinfo: XIV, 391 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• Schlagworte: Adipokines • Adipose tissue • Cardiac dysfunction • circadian rhythms • Energy metabolism • Female reproductive health • Gastrointestinal hormones • Genetics • hormones • Insulin • lipodystrophy • Metabolism • neural control • Obesity • Pancreatic beta cells
• ISBN-10: 1-4419-1607-5 / 1441916075
• ISBN-13: 978-1-4419-1607-5 / 9781441916075