Biopharmaceutical Drug Design and Development (eBook)

Susanna Wu-Pong, Yon Rojanasakul (Herausgeber)

eBook Download: PDF

2010 | 2nd ed. 2008
X, 375 Seiten
Humana Press (Verlag)
978-1-59745-532-9 (ISBN)

Infos

This book provides a comprehensive examination of the newest biopharmaceutical drugs. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immonotherapies including vaccines. Additionally, the volume examines new and emerging technologies, and contains a review of the Human Genome Project.

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Biopharmaceutical Drug Design and Development, Second Edition, furthers the widely successful first edition, published in 1999. This new, expanded edition investigates the dozens of new biopharmaceutical drugs that have become available since that time. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immonotherapies including vaccines. Additionally, the volume examines new and emerging technologies, such as bioinformatics, DNA microarrays, transgenics, therapeutic gene delivery, stem cells, nucleic acid-based therapeutics, and macromolecular drug delivery. Authors also study pharmacogenetics in the clinic and changes in biologic drug approval at the FDA. Biopharmaceutical Drug Design and Development, Second Edition, is a worthy sequel to a discussion on the dynamic, exciting field of biotechnology.

Inhalt

Preface 5
Contents 7
Contributors 9
Biotechnology: 2008 and Beyond 11
The Human Genome Project and Drug Development 25
The Use of Bioinformatics and Chemogenomics in Drug Discovery 40
DNA Microarrays in Drug Discovery and Development 55
Microarray Technology Using Proteins, Cells, and Tissues 75
Pharmacogenetic Issues in Biopharmaceutical Drug Development 106
Development and Applications of Transgenics in Biotechnology and Medicine 128
Viral, Nonviral, and Physical Methods for Gene Delivery 147
Stem Cell Technology and Drug Development 180
Small Nucleic Acid-Based Drugs: Successes and Pitfalls 197
Therapeutic Strategies Targeting the Innate Antiviral Immune Response 226
Pharmacogenetics in the Clinic 255
Molecular Modeling: Considerations for the Design of Pharmaceuticals and Biopharmaceuticals 269
Macromolecular Drug Delivery 294
Changes in Biologic Drug Approval at FDA 325
Follow-On Protein Products: The Age of Biogenerics? 344
Index 366

Produkt-Details

• Erscheint lt. Verlag: 11.1.2010
• Zusatzinfo: X, 375 p. 30 illus., 3 illus. in color.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Allgemeinmedizin
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Pharmazie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Bioinformatics • DNA • enzymes • genes • microarray • monoclonal antibodies • tissue
• ISBN-10: 1-59745-532-6 / 1597455326
• ISBN-13: 978-1-59745-532-9 / 9781597455329