Amino Acid Biosynthesis – Pathways, Regulation and Metabolic Engineering (eBook)

Volker F. Wendisch (Herausgeber)

eBook Download: PDF

2007 | 2007
X, 413 Seiten
Springer Berlin (Verlag)
978-3-540-48596-4 (ISBN)

Infos

This book presents the current knowledge of fundamental as well as applied microbiology of amino acids. Coverage details the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The book also examines the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and as food and feed additives.

Inhalt

Preface 6
References 8
Contents 9
Production of Glutamate and Glutamate- Related Amino Acids: MolecularMechanism Analysis and Metabolic Engineering 11
1 Glutamate 12
2 Short Review of Glutamine and Proline Production 34
References 39
The L-Lysine Story: From Metabolic Pathways to Industrial Production 49
1 Introduction 50
2 Lysine Biosynthetic Pathways 51
3 Corynebacterium glutamicum as a Production Organism 53
4 Strain Engineering 60
5 Industrial Production Processes 68
References 72
L-Threonine 81
1 Introduction 81
2 How Does L-Threonine Production Work? 83
3 What Is Required by the Fermentation Industry? 91
4 Where Is It Going To? 96
References 98
Aromatic Amino Acids 103
1 Introduction 104
2 The General Aromatic Amino Acid Pathway (Shikimate Pathway) 108
References 126
Branched-Chain Amino Acids 138
1 Introduction 139
2 Isoleucine and Valine 141
3 Leucine 155
4 Use of Branched-Chain Amino Acids and their Biotechnological Production 158
References 164
Methionine Biosynthesis in Escherichia coli and Corynebacterium glutamicum 172
1 Introduction 173
2 Methionine Biosynthesis 174
3 Methionine Transformation and Degradation 181
4 Methionine Transport 183
5 Regulation of Methionine Biosynthesis 184
6 Construction of Methionine-Producing Strains 192
7 Conclusion 193
References 194
Cysteine Metabolism and Its Regulation in Bacteria 203
1 Introduction 204
2 Assimilation of Sulfate and Sulfonates 205
3 Cysteine Biosynthetic Pathways 208
4 Cysteine Degradation by Cysteine Desulfhydrases 212
5 Transport of Cystine or Cysteine 212
6 Regulation of Cysteine Biosynthesis and Transport 214
7 Production Process Development 219
References 220
Microbial Arginine Biosynthesis: Pathway, Regulation and Industrial Production 227
1 Introductory Remarks 228
2 The de novo Pathway for Arginine Biosynthesis 231
3 Regulation of Arginine Biosynthesis 239
4 Arginine as a Nutraceutical and Arginine Microbial Production 252
References 254
L-Serine and Glycine 266
1 Features and Use 266
2 L-Serine from Glycine 268
3 L-Serine from Glycine plus C-1 Units 269
4 L-Serine from Glucose 271
References 277
Alanine, Aspartate, and Asparagine Metabolism in Microorganisms 280
1 Alanine 281
2 Aspartate and Asparagine 285
3 Biotechnological Applications 290
References 293
Amino Acid Transport Systems in Biotechnologically Relevant Bacteria 296
1 Introduction 297
2 Basic Properties of Bacterial Amino Acid Transport Systems 298
3 Repertoire of Amino Acid Transporters in C. glutamicum and E. coli 300
4 Particular Amino Acid Transport Systems in C. glutamicum and E. coli 316
5 Conclusions and Perspectives 323
References 324
Occurrence, Biosynthesis, and Biotechnological Production of Dipeptides 333
1 Introduction 334
2 Function of Dipeptides 334
3 Dipeptides and Dipeptide Derivatives from Microorganisms 335
4 Biosynthesis of Dipeptides 339
5 Biotechnology for Dipeptide Manufacturing 343
6 Concluding Remarks 349
References 349
Genomes and Genome-Level Engineering of Amino Acid- Producing Bacteria 355
1 Introduction 356
2 The Corynebacterium glutamicum Genome 358
3 The Escherichia coli Genome 379
4 Genetic Engineering at the Megabase Level 395
5 Perspectives 396
References 397
Subject Index 408

Produkt-Details

• Erscheint lt. Verlag: 24.3.2007
• Reihe/Serie: Microbiology Monographs
• Reihe/Serie: Microbiology Monographs
• Zusatzinfo: X, 413 p. 64 illus., 6 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• Schlagworte: Amino acid • Bacterial metabolism • biochemical engineering • DNA • Enzyme Catalysis • enzymes • Fermentation • food additives • Metabolism • Microbiology • Microorganism • Peptides • Sulphur • transcription • Transport
• ISBN-10: 3-540-48596-1 / 3540485961
• ISBN-13: 978-3-540-48596-4 / 9783540485964