Opportunities and Challenges of the Therapies Targeting CNS Regeneration (eBook)

H.D. Perez, B. Mitrovic, A. Baron Van Evercooren (Herausgeber)

eBook Download: PDF

2007 | 2005
XIII, 186 Seiten
Springer Berlin (Verlag)
978-3-540-27626-5 (ISBN)

Infos

The therapeutic options for the treatment of Multiple Sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer`s, Parkinson`s disease, etc. have experienced enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the inflammatory process (MS) and classical neuroprotection (stroke, AD), therapeutic approaches focusing on active remyelinization and neuronal regeneration have become increasingly important. Based on current concepts, this book summarizes new therapeutic approaches.

Inhalt

Preface 5
Contents 7
List of Editors and Contributors 9
1 New Strategies for CNS Repair 14
2 Heterogeneity of Multiple Sclerosis: Implications for Therapy Targeting Regeneration 24
3 The Neuroprotective Effect of Inflammation: Implications for the Therapy of Multiple Sclerosis 36
4 Fibroblast Growth Factors in Oligodendrocyte Physiology and Myelin Repair 52
5 White Matter Progenitor Cells Reside in an Oligodendrogenic Niche 73
6 At the Interface of the Immune System and the Nervous System: How Neuroinflammation Modulates the Fate of Neural Progenitors In Vivo 94
7 Remyelination and Restoration of Axonal Functionby Glial Cell Transplantation 126
8 Gene and Stem Cell Therapy for Autoimmune Demyelination 144
9 Novel Gene Therapeutic Strategiesfor Neurodegenerative Diseases 158
10 Measuring Injury and Repair of Myelin and Neurons in Multiple Sclerosis 183

Produkt-Details

• Erscheint lt. Verlag: 19.1.2007
• Reihe/Serie: Ernst Schering Foundation Symposium Proceedings
• Reihe/Serie: Ernst Schering Foundation Symposium Proceedings
• Zusatzinfo: XIII, 186 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: central nervous system • Multiple Sclerosis • nervous system • neurodegenerative diseases • Neuroinflammation • neurons • Parkinson • Physiology • Stemm Cell Therapy • Transplantation
• ISBN-10: 3-540-27626-2 / 3540276262
• ISBN-13: 978-3-540-27626-5 / 9783540276265