Biocombinatorial Approaches for Drug Finding (eBook)

W. Wohlleben, T. Spellig, B. Müller-Tiemann (Herausgeber)

eBook Download: PDF

2007 | 2005
XVIII, 284 Seiten
Springer Berlin (Verlag)
978-3-540-27055-3 (ISBN)

Infos

Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research Foundation Workshop 51 was to provide a forum for an open exchange on perspectives and limitations of biocombinatorial synthesis and the significance of this technology for future drug discovery in  light of this challenge. Experts from academia and industry provided contributions covering: the significance of natural compounds for state-of-the-art drug discovery; the underlying basic principle for the biosynthesis of highly complex compounds; and the scope and limitations of combinatorial biosynthesis regarding formation, identification, optimisation, isolation and manufacturing of novel biologically active entities.

Inhalt

Editors 3
Preface 5
Contents 8
List of Editors and Contriiutors 10
1 Protein Domain Fold Similarity and Natural Product Structure as Guiding Principles for Compound Library Design 18
2 Sources of Polyketides and Non-Ribosomal Peptides 36
3 Polyketide Synthases: Mechanisms and Models 59
4 Functional and Structural Basis for Targeted Modification of Non-Ribosomal Peptide Synthetases 95
5 Prerequisites for Combinatorial Biosynthesis: Evolution of Hybrid NRPS/PKS Gene Clusters 123
6 Engineering Glycosylation in Bioactive Compounds by Comiinatorial Biosynthesis 143
7 Glycosyltransferases and Other Tailoring Enzymes as Tools for the Generation of Novel Compounds 163
8 Enzymatic Incorporation of Halogen Atoms into Natural Compounds 180
9 From Glucose to Antiiiotics: What Controls the Fluxes? 210
10 Precursor-Directed Biosynthesis for the Generation of Novel Glycopetides 230
11 Tool-Box: Tailoring Enzymes for Bio-Comiinatorial Lead Development and as Markers for Genome-Based Natural Product Lead Discovery 248
12 Natural Product Biosynthetic Assembly Lines: Prospects and Challenges for Reprogramming 275

Produkt-Details

• Erscheint lt. Verlag: 19.1.2007
• Reihe/Serie: Ernst Schering Foundation Symposium Proceedings
• Reihe/Serie: Ernst Schering Foundation Symposium Proceedings
• Zusatzinfo: XVIII, 284 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Studium
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Combinatorial Biosynthesis • Diversity • Drug • drug discovery • Genome • natural product • Nonribosomal peptides • polyketides • Protein • Proteome • Research • synthesis
• ISBN-10: 3-540-27055-8 / 3540270558
• ISBN-13: 978-3-540-27055-3 / 9783540270553