Transient Receptor Potential (TRP) Channels (eBook)

Veit Flockerzi, Bernd Nilius (Herausgeber)

eBook Download: PDF

2007 | 2007
XIV, 623 Seiten
Springer Berlin (Verlag)
978-3-540-34891-7 (ISBN)

Infos

This volume provides up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field have written 35 essays which describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression.

Inhalt

Preface 6
List of Contents 8
Subject Index 11
An Introduction on TRP Channels 13
TRPC Channel Subfamily 32
TRPC1 Ca2+-Permeable Channels in Animal Cells 33
TRPC2: Molecular Biology and Functional Importance 63
TRPC3: AMultifunctional, Pore-Forming Signalling Molecule 86
Ionic Channels Formed by TRPC4 102
Canonical Transient Receptor Potential 5 118
TRPC6 133
TRPC7 150
TRPV Channel Subfamily 159
Capsaicin Receptor: TRPV1 A Promiscuous TRP Channel 160
2-Aminoethoxydiphenyl Borate as a Common Activator of TRPV1, TRPV2, and TRPV3 Channels 177
TRPV4 192
TRPV5, the Gateway to Ca2+ Homeostasis 209
TRPV6 223
TRPM Channel Subfamily 237
TRPM2 238
TRPM3 254
Insights into TRPM4 Function, Regulation and Physiological Role 269
TRPM5 and Taste Transduction 286
TRPM6: A Janus-Like Protein 298
The Mg2+ and Mg2+-Nucleotide-Regulated Channel- Kinase TRPM7 311
TRPM8 327
Other TRP Channels 343
TRPA1 344
TRPP2 Channel Regulation 360
TRP Proteins and Specific Cellular Functions 373
Know Thy Neighbor: A Survey of Diseases and Complex Syndromes that Map to Chromosomal Regions Encoding TRP Channels 374
TRP Channels of the Pancreatic Beta Cell 404
TRP Channels in Platelet Function 420
TRP Channels in Lymphocytes 439
Link Between TRPV Channels and Mast Cell Function 451
TRPV Channels’ Role in Osmotransduction and Mechanotransduction 466
Nociception and TRP Channels 481
TRP Proteins – Integrators of Multiple Inputs 498
Regulation of TRP Ion Channels by Phosphatidylinositol- 4,5- Bisphosphate 499
TRPC, cGMP-Dependent Protein Kinases and Cytosolic Ca2+ 516
Trafficking of TRP Channels: Determinants of Channel Function 530
TRPC Channels: Interacting Proteins 547
TRPC Channels: Integrators of Multiple Cellular Signals 563
Phospholipase C-Coupled Receptors and Activation of TRPC Channels 580
Subject Index 602
Publisher’s Erratum to Transient Receptor Potential ( TRP) Channels 610
List of Contributors 610

Produkt-Details

• Erscheint lt. Verlag: 7.2.2007
• Reihe/Serie: Handbook of Experimental Pharmacology
• Reihe/Serie: Handbook of Experimental Pharmacology
• Zusatzinfo: XIV, 623 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Pharmazie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Magnesium/Calcium homeostasis • pain perception • Regulation • temperature sensors • TRP Channels • TRP pharmacology
• ISBN-10: 3-540-34891-3 / 3540348913
• ISBN-13: 978-3-540-34891-7 / 9783540348917