The Vascular Endothelium I (eBook)

Salvador Moncada, Annie Higgs (Herausgeber)

eBook Download: PDF

2006 | 2006
IX, 339 Seiten
Springer Berlin (Verlag)
978-3-540-32967-1 (ISBN)

Infos

This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by experts who have made significant contributions to research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of pathologies and their treatment.

Inhalt

Preface 5
List of Contents 7
Contents of Companion Volume 176/II 8
List of Contributors 9
Normal Endothelium 10
1 Central Functional Role of the Endothelium 11
2 Heterogeneity of Endothelial Cells 12
3 Glycocalyx and Endothelial Surface Layer 25
References 37
Functional Ultrastructure of the Vascular Endothelium: Changes in Various Pathologies 50
1 Introduction 51
2 The Many Functions of the Endothelium Enable It to Be Called the Chief Governor of Body Homeostasis 52
3 The Endothelial Cell Structure Supports the Cell Functions 53
4 Basal Lamina 63
5 Innate Phenotypic Heterogeneity of the Vascular Endothelium 65
6 Endothelial Cell Receptors as Operational Tools 66
7 Mechanisms of Endothelial Sorting of Molecules 68
8 Changes of the Vascular Endothelium in Different Pathologies 70
9 Conclusion: Lessons from a Brave Cell 75
References 76
Development of the Endothelium 79
1 Introduction 80
2 Early Endothelial Precursors 81
3 Molecular Differentiation of EC 85
4 Development of Mural Cells 90
5 Endothelium Morphogenesis 98
6 Development of Arteries and Veins 101
7 Concluding Remarks 105
References 105
Transport Across the Endothelium: Regulation of Endothelial Permeability 114
1 Permeability Pathways: Paracellular and Transcytosis 115
2 Mechanisms of Dysregulation of Endothelial Permeability in Inflammation 132
3 Restoration of Endothelial Permeability 137
4 Concluding Remarks 140
References 141
Calcium Signalling in the Endothelium 152
1 Introduction 153
2 Generation of Second Messengers that Release Ca2+ from Intracellular Ca2+ Stores 154
3 Intracellular Ca2+ Stores in Endothelial Cells 157
4 Ca2+ Channels in Endothelial Cells 159
5 Types of Ca2+ Entry in Endothelial Cells 165
6 Regulation of Store-Operated Ca2+ Entry 168
7 Endothelial Nitric Oxide Synthase and Ca2+ Signalling 176
8 Conclusions 181
References 184
Eicosanoids and the Vascular Endothelium 195
1 Introduction 196
2 The COX Pathway 197
3 COX Inhibitors 207
References 210
Nitric Oxide and the Vascular Endothelium 218
1 Introduction 219
2 Nitric Oxide Synthase 220
3 Actions of Nitric Oxide in the Vascular System 227
4 Molecular Targets of the Action of Nitric Oxide 232
5 Nitric Oxide and Pathology 236
6 Conclusion 241
References 241
Angiotensin, Bradykinin and the Endothelium 260
1 Angiotensin 261
2 Bradykinin 269
3 Angiotensin–BK Interactions 273
4 Angiotensin Converting Enzyme (ACE) 279
References 283
Endothelin 300
1 Introduction 301
2 Endothelins and Sarafotoxins 302
3 Endothelin Synthesis 304
4 Endothelin Receptors 310
5 Physiological and Pathophysiological Role 315
6 Conclusions 322
References 323
Subject Index 335
Publisher’s Erratum to The Vascular Endothelium I: Transport Across the Endothelium: Regulation of Endothelial Permeability 344

Produkt-Details

• Erscheint lt. Verlag: 22.12.2006
• Reihe/Serie: Handbook of Experimental Pharmacology
• Reihe/Serie: Handbook of Experimental Pharmacology
• Zusatzinfo: IX, 339 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Medizin / Pharmazie ► Pharmazie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: blood flow • Cardiovascular Disease • Endothelium • gene therapy • lead • Physiology • Vascular Endothelium • Vasculogenesis
• ISBN-10: 3-540-32967-6 / 3540329676
• ISBN-13: 978-3-540-32967-1 / 9783540329671