Th 17 Cells: Role in Inflammation and Autoimmune Disease (eBook)

Valérie Quesniaux, Bernhard Ryffel, Franco Di Padova (Herausgeber)

eBook Download: PDF

2009 | 2009
XII, 244 Seiten
Springer Basel (Verlag)
978-3-7643-8681-8 (ISBN)

Infos

The IL-17 cytokines represent a novel family of cytokines, which defines a new effector T cell, the Th17 cell, and extend the Th1-Th2 paradigm. Th17 cells in part co-express at least IL-17A and IL-17F, IL-21 and IL-22. IL-17 A/F are produced by T cells ( and ), iNKT cells, and possibly neutrophils, dendritic cells and Paneth cells. The regulation of IL-17 family member's expression, and the identification of effector mechanisms are an area of intense current research. Recognized regulators of IL-17A expression include the nuclear receptor ROR t, proinflammatory cyt- ines such as IL-1, IL-6 with TGF- , IL-21, IL-23 IL-25 in the absence of IFN- and IL-4, which are discussed. Recent data suggest that IL-17A may have a dual fu- tion - pro-inflammatory and anti-inflammatory- suggesting that IL-17A may also contribute to terminate inflammation. Further, a reciprocal regulation of Th17 and regulatory T cells including the role of retinoic acid and TGF- is discussed. The discovery that patients with rheumatoid arthritis, allergic disorders, psor- sis and inflammatory bowel disease express IL-17A generated interest in the medical community and instigated a flurry of experimental research on the potential role of Th17 in inflammatory diseases. Experimental studies confirmed that IL-17A is induced and is critical for the development of allergic lung inflammation, arthritis, bacterial sepsis, experimental allergic encephalomyelitis and myocarditis, as well as other inflammatory con- tions including organ transplantation. The role of IL-17F and IL-22 is still poorly defined and is only slowly emerging.

Inhalt

Contents 6
List of contributors 8
Preface 12
Introduction 14
Discovery and IL-17 family 23
IL-22 and IL-17: Common and different properties 24
Other sources of IL-17: Invariant natural killer T cells 50
Contributions of IL-22 to Th17 responses: Repairing and protecting peripheral tissues 60
Retinoic acid in mucosal immune-regulation 72
IL-25, another promoter of allergy 80
Experimental models of disease 92
Critical role of IL-17 in experimental arthritis 93
Dual role of IL-17 in allergic asthma 105
Contribution of IL-17 to the pulmonary inflammatory response 115
The role of IL-17 in experimental autoimmune myocarditis 124
Th17 cells in organ transplantation 136
Role of IL-23/IL-17 in infection and tumor control 142
Is IL-17 required to control tuberculosis? 143
IL-17 and mucosal host defense 156
IL-23 orchestrates the switch from tumor immune surveillance to tumor- promoting inflammation 167
IL-17 in clinical autoimmune disease 179
IL-17 and Th17 cells in rheumatoid arthritis 180
Targeting Th17 cells in CNS immune pathology 190
IL-17 cytokines in asthma 205
IL-17/23, potential targets for Crohn’s disease 214
Novel tools and therapeutic avenues 228
IL-17A and Th17 cells as therapeutic targets for autoimmune diseases 229
Index 242

Produkt-Details

• Erscheint lt. Verlag: 12.3.2009
• Reihe/Serie: Progress in Inflammation Research
• Reihe/Serie: Progress in Inflammation Research
• Zusatzinfo: XII, 244 p. 20 illus.
• Verlagsort: Basel
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Allergic Disorders • Arthritis • Asthma • autoimmune disease • Autoimmune diseases • Cytokine • immune surveillance • immunity • Infection • Infectious • Infectious Diseases • inflammation • inflammatory response • Interleukine • Promoter • Rheumatoid Arthritis • tissue • Transplantation • Tuberculosis • tumor control
• ISBN-10: 3-7643-8681-9 / 3764386819
• ISBN-13: 978-3-7643-8681-8 / 9783764386818