Current Hypotheses and Research Milestones in Alzheimer's Disease (eBook)

Ricardo B. Maccioni, George Perry (Herausgeber)

eBook Download: PDF

2009 | 2009
X, 254 Seiten
Springer US (Verlag)
978-0-387-87995-6 (ISBN)

Infos

Almost four decades of innovative and intensive research on Alzheimer's disease (AD) have brought major advances in our understanding of its pathogenesis, improved tools for diagnosis, and strategies for its treatment. This research has helped build a solid foundation of knowledge in the neurosciences and biological basis of AD and AD-related neurological disorders. Scientific background and insightful hypotheses are of major relevance in order to approach to an effective therapy for this devastating disease.

Current Hypotheses and Research Milestones in Alzheimer's Disease contains 20 seminal chapters by authors with varying views on the neuroanatomical, neuropathological, neuropsychological, neurological, and molecular aspects of AD. These chapters grew out of 'Current Hypothesis on Alzheimer's Disease', held in Viña del Mar, Chile, in November of 2007. Participants included the world's leading Alzheimer's researchers, whose work has illuminated AD investigations during the past few decades.

Students, academics and medical professionals will find this text an invaluable addition to the study of this important subject.

About the authors:

Ricardo B. Maccioni, Ph.D. is a Professor of Neurology at the Medical School and the Department of Biology, Faculty of Sciences, at the University of Chile. George Perry, Ph.D. is the Dean of the College of Sciences at The University of Texas at San Antonio. Dr. Perry received his doctoral degree in marine biology from the Scripps Institution of Oceanography at the University of California at San Diego, served as a postdoctoral fellow in cell biology at Baylor College of Medicine, and earned a bachelor's degree in zoology from the University of California at Santa Barbara. He is an authority on Alzheimer's research; his groundbreaking work brought oxidative stress to the study of AD. This discovery, far in advance of others, has put him among the top dozen most cited investigators studying AD/oxidative stress and among the top 25 neuroscientists in the world. Dr. Perry serves on the editorial board of more than 60 publications and is founding Editor-in-Chief of the highest impact journal in AD research, the Journal of Alzheimer's Disease. He recently won the Denham Harmon Lifetime Achievement Award (discoverer of the Free Radical Theory of Aging) from the American Association for Aging, and currently holds the Zenith Award from the Alzheimer Association.

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Almost four decades of innovative and intensive research on Alzheimer's disease (AD) have brought major advances in our understanding of its pathogenesis, improved tools for diagnosis, and strategies for its treatment. This research has helped build a solid foundation of knowledge in the neurosciences and biological basis of AD and AD-related neurological disorders. Scientific background and insightful hypotheses are of major relevance in order to approach to an effective therapy for this devastating disease.Current Hypotheses and Research Milestones in Alzheimer's Disease contains 20 seminal chapters by authors with varying views on the neuroanatomical, neuropathological, neuropsychological, neurological, and molecular aspects of AD. These chapters grew out of "e;Current Hypothesis on Alzheimer's Disease"e;, held in Via del Mar, Chile, in November of 2007. Participants included the world's leading Alzheimer's researchers, whose work has illuminated AD investigations during the past few decades. Students, academics and medical professionals will find this text an invaluable addition to the study of this important subject.  About the Authors:Ricardo B. Maccioni, Ph.D. is a Professor of Neurology at the Medical School and the Department of Molecular & Cellular Biology at the University of Chile. He also serves as the Director of the Laboratory of Molecular Neurosciences and Scientific Director of the International Center for Biomedicine (ICC). Dr. Maccioni received his doctoral degree in 1975 from the University of Chile, and served as a postdoctoral fellow at the University of Colorado Medical Center in Denver Colorado. He has made several major contributions to the the study of Alzheimer's disease, including his discoveries on the role of tau protein and neuroimmunomodulation in the pathogenesis of this disease, and the design of new in vivo imaging technology and the novel biomarkers for its early diagnosis. He has received more than 60 research grants and several international and national prizes, including the Presidential Chair in Science, the Chancellors medal of the University of Chile, and Doctor Honris causa at several universities. Dr. Macconi has organized over forty international conferences with experts in the neurosciences from around the world. George Perry, Ph.D. is the Dean of the College of Sciences at The University of Texas at San Antonio. Dr. Perry received his doctoral degree in marine biology from the Scripps Institution of Oceanography at the University of California at San Diego, served as a postdoctoral fellow in cell biology at Baylor College of Medicine, and earned a bachelor's degree in zoology from the University of California at Santa Barbara. He is an authority on Alzheimer's research; his groundbreaking work brought oxidative stress to the study of AD. This discovery, far in advance of others, has put him among the top dozen most cited investigators studying AD/oxidative stress and among the top 25 neuroscientists in the world. Dr. Perry serves on the editorial board of more than 60 publications and is founding Editor-in-Chief of the highest impact journal in AD, The Journal of Alzheimer's Disease. He recently won the Denham Harmon Lifetime Achievement Award (discoverer of the Free Radical Theory of Aging) from the American Association for Aging, and currently holds the Zenith Award from the Alzheimer Association.  

Inhalt

Preface 5
Contents 7
Role of A b Degrading Enzymes in SynapticPlasticity and Neurogenesis in Alzheimer’sDisease 11
Pore- Forming Neurotoxin-Like Mechanismfor A b Oligomer-Induced Synaptic Failure 21
Interventions in Aging and Neurodegenerative Disease: Effects on Adult Stem Cells 30
Tau Transgenic Mouse Models in Therapeutic Development 46
What Have We Learned from the Tau Hypothesis? 54
Neuronal Cytoskeleton Regulation and Neurodegeneration 68
Stages of Pathological Tau-Protein Processing in Alzheimer’s Disease: From Soluble Aggregations to Polymerization into Insoluble Tau- PHFs 84
Plasma Membrane-Associated PHF-Core Could be the Trigger for Tau Aggregation in Alzheimer’s Disease 97
Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease 106
Inflammatory Processes Exacerbate Degenerative Neurological Disorders 118
Central Nervous System Inflammation and Cholesterol Metabolism Alterations in the Pathogenesis of Alzheimer’s Disease and Their Diagnostic and Therapeutic Implications 126
Participation of Glial Cells in the Pathogenesis of AD: A Different View on Neuroinflammation 139
Cerebral and Cardiac Vascular Pathology in Alzheimer’s Disease 158
Are Amyloids Infectious? 169
The Possible Link Between Herpes Simplex Virus Type 1 Infection and Neurodegeneration 179
How Biochemical Pathways for Disease May be Triggered by Early- Life Events 202
Strategies for Alzheimer’s Disease Diagnosis 213
The Diagnosis of Dementia in Subjects with Heterogeneous Educational Levels 224
Current Anti-Dementia Drugs: Hypothesis and Clinical Benefits 232
Index 238

Produkt-Details

• Erscheint lt. Verlag: 27.2.2009
• Zusatzinfo: X, 254 p. 135 illus., 35 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
• Themenwelt: Medizin / Pharmazie ► Studium
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Schlagworte: Alzheimer • Alzheimer's disease • dementia • Diagnosis • inflammation • Intervention • nervous system • Neurology • Neuroscience • pathophysiology • Physiology
• ISBN-10: 0-387-87995-1 / 0387879951
• ISBN-13: 978-0-387-87995-6 / 9780387879956