Cardiac Mechanotransduction (eBook)

Matti Weckström, Pasi Tavi (Autoren)

eBook Download: PDF

2007 | 2007
XII, 159 Seiten
Springer New York (Verlag)
978-0-387-48868-4 (ISBN)

Infos

This book presents a multidisciplinary approach to cardiac mechanotransduction. The chapters depict the many faces of the topic, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.

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For about hundred years the investigation of heart physiology has had one central guiding principle, the "e;law"e; of Frank and Starling. This connects the return of blood into the heart and the blood pressure with cardiac con- traction force. The "e;law"e; does it in a way that enables the cardiovascular system to react to perturbations without major malfunctions. This book is a compilation of reviews of prominent scientists on this subject. The differ- ence of the original formulation of the Frank-Starling principle is that mechanotransduction is the central theme that leads the reader through the book. Since the discovery of the "e;law"e; the scope of topics related to this subject has broadened enormously, as can be seen easily by glancing at the contents of this book. Mechanotransduction in the heart has many faces that range from molecules to humans and their diseases. We editors hope that the large amount of knowledge compressed into the book's chapters forms a balanced treatment and that the text is easily approached by all who want to know what cardiac mechanotransduction is about. Matti Weckstrom and Pasi Tavi Oulu, Finland June 16. 2006 Ackno^vledgments The editors are grateful to all authors for their magnificent contributions and for their patience during compiling this book. This work was supported by the University of Oulu, the Biocenter Oulu and the Academy of Finland.

Inhalt

CONTENTS 5
PREFACE 10
CHAPTER 1 The Mechanosensory Heart: A Multidisciplinary Approach 12
CHAPTER 2 Origin of Mechanotransduction: Stretch-Activated Ion Channels 19
CHAPTER 3 The Role of the Sarcomere and Cytoskeleton in Cardiac Mechanotransduction 39
CHAPTER 4 Mechanoelectric Transduction/Feedback: Physiology and Pathophysiology 59
CHAPTER 5 Mechanotransduction in Girdiac Remodeling and Heart Failure 89
CHAPTER 6 Second Messenger Systems Involved in Heart Mechanotransduction 104
CHAPTER 7 The Role of Adrenoceptors in Mechanotransduction 117
CHAPTER 8 Intracellular Signaling Through Protein Kinases in Cardiac Mechanotransduction 131
CHAPTER 9 Mechanotransduction of the Endocrine Heart: Paracrine and Intracellular Regulation of B-Type Natriuretic Peptide Synthesis 145
Index 156

Produkt-Details

• Erscheint lt. Verlag: 22.12.2007
• Zusatzinfo: XII, 159 p. 46 illus.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: biochemistry • Cardiac • Chemistry • Cytoskeleton • heart • ion channels • Mechanotransduction • Membrane • pathophysiology • pharmacology • Physiology • Protein • Regulation • Weckström
• ISBN-10: 0-387-48868-5 / 0387488685
• ISBN-13: 978-0-387-48868-4 / 9780387488684