The Leydig Cell in Health and Disease (eBook)

Anita H. Payne, Matthew P. Hardy (Herausgeber)

eBook Download: PDF

2007 | 2007
XII, 476 Seiten
Humana Press (Verlag)
978-1-59745-453-7 (ISBN)

Infos

This book provides a comprehensive study of the Leydig cell, a fascinating and important cell type. It presents all of the developments in our understanding of Leydig cell biology and explores a wide variety of current and potential clinical applications. All aspects of Leydig cell biology, development, regulation, and physiology are explored in thirty-one expertly written chapters. This in-depth volume is an invaluable resource.

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Nearly ten years after they published the first book devoted entirely to the Leydig cell, Matthew Hardy and Anita Payne have collaborated again to provide a comprehensive study of this fascinating and important cell type. The Leydig Cell in Health and Disease presents all of the developments in our understanding of Leydig cell biology and explores a wide variety of current and potential clinical applications. All aspects of Leydig cell biology, development, regulation, and physiology are explored in thirty-one expertly written chapters. The Leydig Cell in Health and Disease explores topics of great interest to the private sector, including the possible application of steroidogenesis discoveries to androgen synthesis or suppressing Leydig cell function as a key mechnanism in the development of a male contraceptive. This in-depth volume is an invaluable resource for information on the science and application of Leydig cell biology and function.

Inhalt

PREFACE 6
CONTENTS 8
CONTRIBUTORS 10
LIST OF COLOR IMAGES 12
I HISTORICAL 14
1 A History of Leydig Cell Research 15
II CELL BIOLOGY 43
2 Structural and Histological Analysis of Leydig Cell Steroidogenic Function 44
3 Fetal Leydig Cells 57
4 Regulation of Leydig Cells During Pubertal Development 65
5 The Human Leydig Cell 81
6 Dynamics of Leydig Cell Regeneration After EDS 100
7 Aging and the Decline of Androgen Production 126
III STEROIDOGENESIS 141
8 Regulation of Leydig Cell Cholesterol Metabolism 142
9 The Role of StAR in Leydig Cell Steroidogenesis 156
10 Steroidogenic Enzymes in Leydig Cells 163
11 Development of Leydig Cell Steroidogenesis 178
12 Peripheral Testosterone Metabolism 185
13 Leydig Cell Aromatase 193
14 The Role of Estrogen Sulfotransferase in Leydig Cells 200
15 Endocrinology of Leydig Cells in Nonmammalian Vertebrates 209
IV REGULATION 227
16 The Luteinizing Hormone Receptor 228
17 Insights Into Leydig Cell Function From Mice With Genetically Modified Gonadotropin Action 254
18 Growth Factors in Leydig Cell Function 263
19 Insulin-Like Peptide 3 in Leydig Cells 278
20 Neuronal Signaling Molecules and Leydig Cells 289
21 Regulation of Leydig Cell Function as it Pertains to the Inflammatory Response 303
22 Activins and Leydig Cell Development, Differentiation, and Disease 320
23 Transcription Factors as Regulators of Gene Expression During Leydig Cell Differentiation and Function 329
24 Androgen Receptor in Leydig Cell Function and Development 340
V PHYSIOLOGY AND APPLIED ASPECTS 358
25 Fluid Exchange and Transport of Hydrophilic Factors in the Testis 359
26 Immortalized Leydig Cell Lines as Models for Studying Leydig Cell Physiology 367
27 Induction of Leydig Cell Tumors by Xenobiotics 376
28 Environmental Factors That Disrupt Leydig Cell Steroidogenesis 386
29 The Leydig Cell as a Target for Male Contraception 407
30 Clinical Evaluation of Leydig Cell Function 435
INDEX 459

Produkt-Details

• Erscheint lt. Verlag: 28.10.2007
• Reihe/Serie: Contemporary Endocrinology
• Reihe/Serie: Contemporary Endocrinology
• Zusatzinfo: XII, 476 p. 79 illus., 2 illus. in color.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: cell lines • Cells • gene expression • genes • Gonadotropin • Growth factor • insulin-like • Physiology • transcription
• ISBN-10: 1-59745-453-2 / 1597454532
• ISBN-13: 978-1-59745-453-7 / 9781597454537