Genomics in Endocrinology (eBook)

DNA Microarray Analysis in Endocrine Health and Disease

Stuart Handwerger, Bruce J. Aronow (Herausgeber)

eBook Download: PDF

2007 | 2008
XI, 288 Seiten
Humana Press (Verlag)
978-1-59745-309-7 (ISBN)

Infos

Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The text provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed include the methodology of DNA microarrays and general methods for the analysis of microarray data.

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In recent years, the development of new technologies capable of monitoring genome function has resulted in fewer hopeful estimates and increasingly solid depictions of genome output from individual samples. Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The volume provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed are the methodology of DNA microarrays and general methods for the analysis of microarray data, as well as studies of a wide variety of normal and abnormal endocrine cells. In the introductory chapter, the volume s editors describe several issues in hypothesis formulation, experimental design, data analysis, and follow-up studies that may corroborate, validate, and extend hypotheses gained through microarray analyses. The contributed chapters span a variety of applications that we have divided into the areas of (1) genomic insights into molecular mechanisms responsible for hormone action, (2) genomic characterizations of endocrine producing tissues, and (3) genomic manifestations of diseases of hormonal systems.A volume on the cutting-edge of technology, Genomics in Endocrinology will provide researchers with an authoritative volume on the most recent advances in monitoring genome function.

Inhalt

Preface 6
Contents 7
Contributors 9
I Introduction 12
1 Microarray-based Gene Expression Analysis of Endocrine Systems: Principles of Experimental Design and Interpretation 13
II Hormone Action and Molecular Mechanisms 33
2 Gene Expression Profiles and Transcription Factors Involved in Parathyroid Hormone Signaling in Osteoblastic Cells 34
3 Analysis of Growth Hormone Effects on Hepatic Gene Expression in Hypophysectomized Rats 49
4 Gene Expression Profiling in Leiomyoma in Response to GnRH Therapy and TGF- ß 75
5 Gene Profiling Analysis of Androgen Receptor Mediated Function 91
6 Interrogating Estrogen Receptor Signaling in Breast Cancer by Chromatin Immunoprecipitation Microarrays 122
7 Gene Expression Analysis of the Adrenal Cortex in Health and Disease 137
III Endocrine Producing Tissues 150
8 DNA Microarray Analysis of Human Uterine Decidualization 151
9 Large-scale DNA Microarray Data Analysis Reveals Glucocorticoid Receptor- mediated Breast Cancer Cell Survival Pathways 169
10 Application of Microarrays for Gene Transcript Analysis in Type 2 Diabetes 188
11 DNA Microarray Analysis of Effects of TSH, Iodide, Cytokines, and Therapeutic Agents on Gene Expression in Cultured Human Thyroid Follicles 209
IV Diseases of Hormonal Systems 218
12 Genomics and Polycystic Ovary Syndrome ( PCOS): The Use of Microarray Analysis to Identify New Candidate Genes 219
13 Microarray Analysis of Alterations Induced by Obesity in White Adipose Tissue Gene Expression Profiling 238
14 Novel Molecular Signaling and Classification of Human Clinically Nonfunctioning Pituitary Adenomas Identified by Microarray and Reverse Transcription- Quantitative Polymerase Chain Reaction 262
15 Gene Expression Studies of Prostate Hyperplasia in Prolactin Transgenic Mice 270
Index 281

Produkt-Details

• Erscheint lt. Verlag: 26.12.2007
• Reihe/Serie: Contemporary Endocrinology
• Reihe/Serie: Contemporary Endocrinology
• Zusatzinfo: XI, 288 p.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Abnormal endocrine cells • Diabetes • DNA • DNA microarrays • Estrogen Receptor • gene expression • genes • hormone signaling • microarray • Molecular mechanisms • Normal endocrine cells • Prolactin • receptor signaling • transcription • transcription factors
• ISBN-10: 1-59745-309-9 / 1597453099
• ISBN-13: 978-1-59745-309-7 / 9781597453097