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Brain Diseases and Metalloproteins -

Brain Diseases and Metalloproteins

David R. Brown (Herausgeber)

Buch | Hardcover
438 Seiten
2012
Pan Stanford Publishing Pte Ltd (Verlag)
978-981-4316-01-9 (ISBN)
CHF 239,95 inkl. MwSt
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This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson’s disease, Alzheimer’s disease, prion disease, and ALS. The chapters separately examine such issues as mechanisms of metal binding, metal-induced structural changes in proteins, alterations in cellular metal metabolism in disease, and attempts at a therapeutic approach based on protein metal binding.

David R. Brown

1. Introduction, 2. A Possible Key Role for Redox-Active Metal Ions and Soluble Oligomers in Neurodegenerative Disease, 3. Modelling of the Metal Binding Sites in Proteins Involved in Neurodegeneration, 4. Mammalian Metallothioneins, 5. Copper Transporting P-Type ATPases in the Brain, 6. Role of the Amyloid Precursor Protein and Copper in Alzheimer’s Disease, 7. Role of Aluminum and Other Metal Ions in the Pathogenesis of Alzheimer’s Disease, 8. Prion Diseases, Metals and Antioxidants, 9. Emerging Role for Copper-Bound ?-Synuclein in Parkinson’s Disease Etiology, 10. Interactions of ?-Synuclein with Metal Ions: New Insights into the Structural Biology and Bioinorganic Chemistry of Parkinson’s Disease, 11. An Attempt to Treat Amyotrophic Lateral Sclerosis by Intracellular Copper Modification Using Ammonium Tetrathiomolybdate and/or Metallothionein: Fundamentals and Perspective, Index

Erscheint lt. Verlag 7.8.2012
Zusatzinfo 23 Illustrations, color; 43 Illustrations, black and white
Verlagsort Singapore
Sprache englisch
Maße 152 x 229 mm
Gewicht 970 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Studium Querschnittsbereiche Infektiologie / Immunologie
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Chemie
ISBN-10 981-4316-01-6 / 9814316016
ISBN-13 978-981-4316-01-9 / 9789814316019
Zustand Neuware
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