Protein-Ligand Interactions
De Gruyter (Verlag)
978-3-11-004881-0 (ISBN)
Frontmatter -- Preface -- Section I. General -- Letter from J. Wyman to the Members of the Symposium -- Concerted Changes in an Allosteric Macromolecule -- Ligand Interactions in Globular Proteins -- Discussion -- Ligand Binding to Enzyme Complexes -- Discussion -- Properties of Polymeric Proteins Bound to Solid Matrices: Subunit Exchange Chromatography -- Discussion -- Contributions of Aromatic Amino Acid Residues to the Optical Activity of Protein-Ligand Complexes -- Discussion -- Section II. Enzymes -- The Architecture of the Coenzyme Binding Domain in Dehydrogenases as Revealed by X-Ray Structure Analysis -- Discussion -- The Interaction of Glutamate Dehydrogenase with a Coenzyme Analog -- Discussion -- The Interaction of Adenosine Triphosphate and its Analogs with Myosin and the Modification by Actin -- Discussion -- Isolation of a Guanylnucleotide Binding Protein from Pigeon Erythrocyte Membranes -- Discussion -- On the Binding of Isoleucine and Related Amino Acids to Isoleucyl-tRNA Synthetase from Escherichia Coli MRE 600 -- Discussion -- The Effect of Small Molecules on the Affinity of Individual Chains in Hemoglobin and on its Cooperativity -- Discussion -- Cooperative Interactions without Symmetry or Subunits -- Discussion -- A Nuclear Magnetic Resonance Study of Activator Binding by Carboxypeptidase A -- Discussion -- Section III. Repressors -- Lactose Operator Sequences and the Action of Lac Repressor -- Discussion -- The Active Sites of Lac Repressor -- Discussion -- Lac Repressor -- Discussion -- The Use of Suppressed Nonsense Mutations to Generate Altered Lac Repressor Molecules -- Discussion -- Effect of Alterations in Lac Operator DNA on Repressor Binding -- Discussion -- Interaction of Lac Repressor with Non-Specific DNA Binding Sites -- Discussion -- Section IV. Receptors -- Binding and Functional States of the Cholinergic Receptor Protein from Torpedo Marmorata -- Discussion -- Subunit Structure and Binding Sites of the Acetylcholine Receptor -- Discussion -- Further Characterization of Purified Acetylcholine Receptor and its Incorporation into Phospholipid Vesicles -- Discussion -- Structural and Functional Studies of an Acetylcholine Receptor -- Discussion -- Section V. Antibodies, Drugs and Metabolites -- Antibody Combining Sites as a Model for Molecular Recognition -- Discussion -- Antibiotic Action on Enzymes Involved in Peptidoglycan Synthesis -- Discussion -- Problems in Studying Protein Binding with Regard to the Interaction of Steroids with a Specific Binding Globulin -- Discussion -- The Interaction of Low-Molecular Compounds with Serum Albumin as Measured by Optical Methods. Circular Dichroism of Bilirubin-Human Serum Albumin Complexes in the Presence of Alcohols in Aqueous Solution -- Discussion -- Section VI. Detergents and Electrolytes -- The Nature of Specific and Non-Specific Interactions of Detergents with Proteins: Complexing and Unfolding -- Discussion -- Interaction of Detergents with Proteins: Effect of Counter Ions on the System Ferrimyoglobin- Laurylpyridinium Halides in Aqueous Medium -- Discussion -- Influence of Ions on the Kinetics of Cooperative Conformational Changes in Globular Proteins -- Discussion -- Neutral Salt Effects on the Conformational Stability of Biological Macromolecules -- Discussion -- Concluding Remarks -- Index of Contributors -- Subject Index -- Backmatter
Frontmatter -- Preface -- Section I. General -- Letter from J. Wyman to the Members of the Symposium -- Concerted Changes in an Allosteric Macromolecule -- Ligand Interactions in Globular Proteins -- Discussion -- Ligand Binding to Enzyme Complexes -- Discussion -- Properties of Polymeric Proteins Bound to Solid Matrices: Subunit Exchange Chromatography -- Discussion -- Contributions of Aromatic Amino Acid Residues to the Optical Activity of Protein-Ligand Complexes -- Discussion -- Section II. Enzymes -- The Architecture of the Coenzyme Binding Domain in Dehydrogenases as Revealed by X-Ray Structure Analysis -- Discussion -- The Interaction of Glutamate Dehydrogenase with a Coenzyme Analog -- Discussion -- The Interaction of Adenosine Triphosphate and its Analogs with Myosin and the Modification by Actin -- Discussion -- Isolation of a Guanylnucleotide Binding Protein from Pigeon Erythrocyte Membranes -- Discussion -- On the Binding of Isoleucine and Related Amino Acids to Isoleucyl-tRNA Synthetase from Escherichia Coli MRE 600 -- Discussion -- The Effect of Small Molecules on the Affinity of Individual Chains in Hemoglobin and on its Cooperativity -- Discussion -- Cooperative Interactions without Symmetry or Subunits -- Discussion -- A Nuclear Magnetic Resonance Study of Activator Binding by Carboxypeptidase A -- Discussion -- Section III. Repressors -- Lactose Operator Sequences and the Action of Lac Repressor -- Discussion -- The Active Sites of Lac Repressor -- Discussion -- Lac Repressor -- Discussion -- The Use of Suppressed Nonsense Mutations to Generate Altered Lac Repressor Molecules -- Discussion -- Effect of Alterations in Lac Operator DNA on Repressor Binding -- Discussion -- Interaction of Lac Repressor with Non-Specific DNA Binding Sites -- Discussion -- Section IV. Receptors -- Binding and Functional States of the Cholinergic Receptor Protein from Torpedo Marmorata -- Discussion -- Subunit Structure and Binding Sites of the Acetylcholine Receptor -- Discussion -- Further Characterization of Purified Acetylcholine Receptor and its Incorporation into Phospholipid Vesicles -- Discussion -- Structural and Functional Studies of an Acetylcholine Receptor -- Discussion -- Section V. Antibodies, Drugs and Metabolites -- Antibody Combining Sites as a Model for Molecular Recognition -- Discussion -- Antibiotic Action on Enzymes Involved in Peptidoglycan Synthesis -- Discussion -- Problems in Studying Protein Binding with Regard to the Interaction of Steroids with a Specific Binding Globulin -- Discussion -- The Interaction of Low-Molecular Compounds with Serum Albumin as Measured by Optical Methods. Circular Dichroism of Bilirubin-Human Serum Albumin Complexes in the Presence of Alcohols in Aqueous Solution -- Discussion -- Section VI. Detergents and Electrolytes -- The Nature of Specific and Non-Specific Interactions of Detergents with Proteins: Complexing and Unfolding -- Discussion -- Interaction of Detergents with Proteins: Effect of Counter Ions on the System Ferrimyoglobin- Laurylpyridinium Halides in Aqueous Medium -- Discussion -- Influence of Ions on the Kinetics of Cooperative Conformational Changes in Globular Proteins -- Discussion -- Neutral Salt Effects on the Conformational Stability of Biological Macromolecules -- Discussion -- Concluding Remarks -- Index of Contributors -- Subject Index -- Backmatter
| Erscheint lt. Verlag | 1.3.1975 |
|---|---|
| Zusatzinfo | Num. figs. |
| Verlagsort | Berlin/Boston |
| Sprache | deutsch |
| Maße | 170 x 240 mm |
| Gewicht | 10 g |
| Themenwelt | Schulbuch / Wörterbuch ► Lexikon / Chroniken |
| Naturwissenschaften ► Chemie ► Allgemeines / Lexika | |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Schlagworte | /2 • ADL54 • Allgemeines, Lexika • ausgewaehlte • biochemistry • Congresses • Eiweiss • German • Gottsched • interaction • Life Sciences • Ligand • Ligands (Biochemistry) • Ligands (Biochemistry) -- Congresses • Protein • Protein binding • proteins • Proteins -- Congresses • Science • Tanz • Universität • University • Werke |
| ISBN-10 | 3-11-004881-7 / 3110048817 |
| ISBN-13 | 978-3-11-004881-0 / 9783110048810 |
| Zustand | Neuware |
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