The Epothilones: An Outstanding Family of Anti-Tumor Agents

From Soil to the Clinic

Buch | Softcover

IX, 260 Seiten

2010 | 1. Softcover reprint of hardcover 1st ed. 2009
Springer Wien (Verlag)
978-3-211-99928-8 (ISBN)

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Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.

General Aspects.- Biosynthesis and Heterologous Production of Epothilones.- Total Synthesis of Epothilones A-F.- Semisynthetic Derivatives of Epothilones.- Preclinical Pharmacology and Structure-Activity Studies of Epothilones.- Clinical Studies with Epothilones.

Erscheint lt. Verlag	19.10.2010
Reihe/Serie	Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products
Co-Autor	Karl-Heinz Altmann, Gerhard Höfle, Rolf Müller, Kathrin Prantz
Mitarbeit	Herausgeber (Serie): A. Douglas Kinghorn
Zusatzinfo	IX, 260 p.
Verlagsort	Vienna
Sprache	englisch
Maße	155 x 235 mm
Gewicht	421 g
Themenwelt	Naturwissenschaften ► Chemie ► Organische Chemie
Schlagworte	anti-tumour agent • anti-tumour drug • Apoptosis • biochemistry • Chemistry • epothilone • Expression • Genetic Engineering • Krebstherapie
ISBN-10	3-211-99928-0 / 3211999280
ISBN-13	978-3-211-99928-8 / 9783211999288
Zustand	Neuware