Peptide-Based Drug Design
Humana Press Inc. (Verlag)
978-1-61737-869-0 (ISBN)
Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular Biology™ series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls.
Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.
Peptide-Based Drug Design: Here and Now.- Strategies for the Discovery, Isolation, and Characterization of Natural Bioactive Peptides from the Immune System of Invertebrates.- Sequence Analysis of Antimicrobial Peptides by Tandem Mass Spectrometry.- The Spot Technique: Synthesis and Screening of Peptide Macroarrays on Cellulose Membranes.- Analysis of A? Interactions Using ProteinChip Technology.- NMR in Peptide Drug Development.- Molecular Dynamics Simulations of Peptides.- Short Linear Cationic Antimicrobial Peptides: Screening, Optimizing, and Prediction.- Investigating the Mode of Action of Proline-Rich Antimicrobial Peptides Using a Genetic Approach: A Tool to Identify New Bacterial Targets Amenable to the Design of Novel Antibiotics.- Serum Stability of Peptides.- Preparation of Glycosylated Amino Acids Suitable for Fmoc Solid-Phase Assembly.- Synthesis of O-Phosphopeptides on Solid Phase.- Peptidomimetics: Fmoc Solid-Phase Pseudopeptide Synthesis.- Synthesis of Toll-Like Receptor-2 Targeting Lipopeptides as Self-Adjuvanting Vaccines.- Synthesis of a Multivalent, Multiepitope Vaccine Construct.- Cysteine-Containing Fusion Tag for Site-Specific Conjugation of Therapeutic and Imaging Agents to Targeting Proteins.
| Erscheint lt. Verlag | 19.11.2010 |
|---|---|
| Reihe/Serie | Methods in Molecular Biology ; 494 |
| Zusatzinfo | XI, 303 p. |
| Verlagsort | Totowa, NJ |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Medizin / Pharmazie ► Pharmazie | |
| Medizin / Pharmazie ► Studium ► 1. Studienabschnitt (Vorklinik) | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| ISBN-10 | 1-61737-869-0 / 1617378690 |
| ISBN-13 | 978-1-61737-869-0 / 9781617378690 |
| Zustand | Neuware |
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