Computer Techniques in Preclinical and Clinical Drug Development
Seiten
1996
Crc Press Inc (Verlag)
978-0-8493-7682-5 (ISBN)
Crc Press Inc (Verlag)
978-0-8493-7682-5 (ISBN)
This text responds to the question "how can we use computational methods to improve the success rate in drug development?" It aims to show how modelling makes it possible to extract the maximum amount of information and predictive value from preclinical data.
It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development?" Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.
It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development?" Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.
Jackson, Robert C.
Introduction: The Preclinical and Clinical Drug Development Process Physiological Pharmacokinetic Modeling Interspecies Scaling Prediction of Drug Metabolism and Toxicity Pharmacodynamic Modeling Cytokinetic Modeling Prediction of Drug Resistance Conclusions: The Virtual Clinical Trial References Appendix: Computational Pharmacology Software Suppliers Abbreviations Index
| Erscheint lt. Verlag | 23.7.1996 |
|---|---|
| Verlagsort | Bosa Roca |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 498 g |
| Einbandart | gebunden |
| Themenwelt | Informatik ► Grafik / Design ► Digitale Bildverarbeitung |
| Medizin / Pharmazie ► Gesundheitswesen | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Naturwissenschaften ► Biologie | |
| Technik | |
| ISBN-10 | 0-8493-7682-3 / 0849376823 |
| ISBN-13 | 978-0-8493-7682-5 / 9780849376825 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
Mehr entdecken
aus dem Bereich
aus dem Bereich
Modelle für 3D-Druck und CNC entwerfen
Buch | Softcover (2022)
dpunkt (Verlag)
CHF 48,85
alles zum Drucken, Scannen, Modellieren
Buch | Softcover (2024)
Markt + Technik Verlag
CHF 34,90
