Antisense Therapeutics

Buch | Softcover

344 Seiten

2010 | Softcover reprint of hardcover 2nd ed. 2005
Humana Press Inc. (Verlag)
978-1-61737-421-0 (ISBN)

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A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.

Antisense Therapeutics.- Antisense Inhibition.- Cardiovascular.- Local Application of Antisense for Prevention of Restenosis.- Antisense Therapeutics for Hypertension.- Antisense Strategies for the Treatment of Heart Failure.- Cancer.- Clinical Studies of Antisense Oligonucleotides for Cancer Therapy.- Antisense Therapy in Clinical Oncology.- Radionuclide-Peptide Nucleic Acid in Diagnosis and Treatment of Pancreatic Cancer.- uppression of Pancreatic and Colon Cancer Cells by Antisense K-ras RNA Expression Vectors.- Induction of Tumor Cell Apoptosis and Chemosensitization by Antisense Strategies.- Utility of Antioncogene Ribozymes and Antisense Oligonucleotides in Reversing Drug Resistance.- Blood—Brain Barrier.- Transport of Antisense Across the Blood-Brain Barrier.- Dermal.- Transdermal Delivery of Antisense Oligonucletoides.- Drugs.- Antisense Strategies for Redirection of Drug Metabolism.- Gastrointestinal.- Antisense Oligonucleotide Treatment of Inflammatory Bowel Diseases.- Hepatitis.- Optimizing Electroporation Conditions for Intracellular Delivery of Morpholino Antisense Oligonucleotides Directed Against the Hepatitis C Virus Internal Ribosome Entry Site.

Erscheint lt. Verlag	10.11.2010
Reihe/Serie	Methods in Molecular Medicine ; 106
Zusatzinfo	56 Illustrations, black and white; 344 p. 56 illus.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	152 x 229 mm
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Themenwelt	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	1-61737-421-0 / 1617374210
ISBN-13	978-1-61737-421-0 / 9781617374210
Zustand	Neuware