Biochemistry and Molecular Biology of Antimicrobial Drug Action

Trevor J. Franklin, George Alan Snow (Autoren)

Buch | Softcover

182 Seiten

2010 | Softcover reprint of hardcover 6th ed. 2005
Springer-Verlag New York Inc.
978-1-4419-3549-6 (ISBN)

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Preface to the sixth edition x 1 THE DEVELOPMENT OF ANTIMICROBIAL AGENTS, PAST, PRESENT AND FUTURE 1 1. 1 The social and economic importance of antimicrobial agents 1 1. 2 All outhne of the historical development of antimicrobial agents 2 1. 3 Reasons for studying the biochemistry and molecular biology of antimicrobial compounds 9 1. 4 Uncovering the molecular basis of antimicrobial action iO 1. 5 Current trends in the discovery of antimicrobial drugs 14 1. 6 . Scope and layout of the book 15 2 VULNERABLE SHIELDS—THE CELL WALLS OF BACTERIA AND FUNGI 17 2. 1 Functions of the ceU wall 17 2. 2 . Structure of the bacterial wall 17 2. 3 Structure and biosynthesis of peptidoglycan 22 2. 4 Antibiotics that inhibit peptidoglycan biosynthesis 29 2. 5 Drugs that interfere with the biosynthesis of the cell wall of mycobacteria 39 2. 6 The fungal cell wall as a target for antifungal drugs 41 3 ANTIMICROBIAL AGENTS AND CELL MEMBRANES 47 3. 1 Microbe killers: antiseptics and disinfectants 47 3. 2 Cationic peptide antibiotics 52 3. 3 lonophoric antibiotics 54 3. 4 Antifungal agents that interfere with the function and biosynthesis of membrane sterols 59 4 INHIBITORS OF NUCLEIC ACID BIOSYNTHESIS 65 4. 1 Compounds affecting the biosynthesis and utilization of nucleotide precursors 66 4. 2 Nucleoside analogues 70 4. 3 Inhibitors of the reverse transcriptase of the human immunodeficiency virus 72 4. 4 Antibacterial inhibitors of topoisomerases 75 4.

The development of antimicrobial agents, past, present and future.- Vulnerable shields—the cell walls of bacteria and fungi.- Antimicrobial agents and cell membranes.- Inhibitors of nucleic acid biosynthesis.- Inhibitors of protein biosynthesis.- Antimicrobial drugs with other modes of action.- Attack and defense: drug transport across cell walls and membranes.- The genetic basis of resistance to antimicrobial drugs.- Biochemical mechanisms of resistance to antimicrobial drugs.

Erscheint lt. Verlag	15.10.2010
Zusatzinfo	3 Illustrations, color; 89 Illustrations, black and white; X, 182 p. 92 illus., 3 illus. in color.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-4419-3549-5 / 1441935495
ISBN-13	978-1-4419-3549-6 / 9781441935496
Zustand	Neuware