Inflammation in the Pathogenesis of Chronic Diseases

The COX-2 Controversy

Buch | Softcover

324 Seiten

2010 | Softcover reprint of hardcover 1st ed. 2007
Springer (Verlag)
978-90-481-7429-4 (ISBN)

Artikel merken

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.

Historical Perspectives.- Anti-Inflammatory Drugs in the 21st Century.- Inflammatory Mechanisms of Pathogenesis.- Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus.- Obesity, Inflammation, and Vascular Disease.- Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer.- Role of COX-2 in Inflammatory and Degenerative Brain Diseases.- Inflammation and Cardiovascular Disease: The Coxib Controversy.- Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors.- COX-2 Inhibitors And Cardiovascular Risk.- A Biological Rationale for the Cardiotoxic Effects of Rofecoxib.- Cox-2 Blockade in Cancer Prevention and Therapy.- Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade.- Strategies for Colon Cancer Prevention.- Inflammation and Neurodegenerative Disease.- NSAIDs for the Chemoprevention of Alzheimer’s Disease.- Inflammation in parkinson’s disease.- Nutrition, Inflammation and Chronic Disease.- Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases.- Nutritional Intervention in Brain Aging.

From the reviews:

“This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition. … Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. … It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library.” (Vladimir N. Despotovic, Doody’s Review Service, February, 2010)

Erscheint lt. Verlag	22.11.2010
Reihe/Serie	Subcellular Biochemistry ; 42
Zusatzinfo	XIV, 324 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	90-481-7429-5 / 9048174295
ISBN-13	978-90-481-7429-4 / 9789048174294
Zustand	Neuware