Antibodies in Viral Infection

Buch | Softcover

IX, 309 Seiten

2010 | 2001
Springer Berlin (Verlag)
978-3-642-07486-8 (ISBN)

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Antibodies are central to vaccines and it is becoming increasingly apparent that understanding how antibodies combat viruses could be crucial in a new era of vaccine development. This book describes the state of the art in explaining the anti-viral activity of antibodies at the molecular level, with chapters from many of the leaders in the field. The huge mortality and morbidity of the AIDS pandemic and outbreaks due to emerging pathogens such as Ebola virus and hantavirus underline the vulnerability of mankind to viral infection. By far the most successful anti-viral strategy to date has been vaccination but the development of vaccines against viruses such as HIV, the cause of AIDS, is proving difficult. Antibodies are central to vaccines and it is becoming increasingly apparent that understanding how antibodies combat viruses could be crucial in a new era of vaccine development. This book describes the state of the art in explaining the anti-viral activity of antibodies at the molecular level with chapters from many of the leaders in the field. It will appeal to anyone interested in the fight against viruses.

List of Contents.- Antibody Interactions with Rhinovirus: Lessons for Mechanisms of Neutralizationand the Role of Immunity in Viral Evolution.- Structural Studies on Antibody Interacting with Viruses.- Shape and Electrostatic Complementarity at Viral Antigen-Antibody Complexes.- Structural Studies on Viral Escape from Antibody Neutralization.- Affinity, Complementarity, Cooperativity, and Specificity in Antibody Recognition.- Mechanisms of Virus Neutralization by Antibody.- A Model for Neutralization of Viruses Based on Antibody Coating of the Virion Surface.- Antibody-Mediated Enhancement of Viral Disease.- The Role of the Antibody Response in Influenza Virus Infection.- Role of Antibodies in Controlling Alphavirus Infection of Neurons.- Role of Mucosal Antibodies in Viral Infections.- The Role of the Complement System in Virus Infections.- Intrabodies as Antiviral Agents.- T-Bodies as Antiviral Agents.

Erscheint lt. Verlag	1.12.2010
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	IX, 309 p. 51 illus., 12 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	489 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	antibody coating • antibody complexes • antibody interactions • antibody recognition • anti-viral agents • viral disease • virus infection
ISBN-10	3-642-07486-3 / 3642074863
ISBN-13	978-3-642-07486-8 / 9783642074868
Zustand	Neuware