Reviews of Physiology, Biochemistry and Pharmacology 156

Susan G. Amara, Ernst Bamberg, Sergio Grinstein, Steven C. Hebert, Reinhard Jahn, W.J. Lederer, Roland Lill, Atsushi Miyajima, H. Murer, Stefan Offermanns, G. Schultz, M. Schweiger (Herausgeber)

Buch | Softcover

IV, 90 Seiten

2010 | 1. Softcover reprint of hardcover 1st ed. 2006
Springer Berlin (Verlag)
978-3-642-06824-9 (ISBN)

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Gastric acid plays a primary role in digestion as well as in the sterilization of food and water. Gastric juice contains the most concentrated physiological acid solution (pH~1) as a result + - of H and Cl ion secretion [hydrochloric acid (HCl) production] by parietal cells in the oxyntic mucosa of the stomach. The combined output of the parietal cells leads to the sec- tion of 1-2 l of HCl at a concentration of 150-160 mmol/l into the interior of the stomach. In order to facilitate the production of acid, the parietal cell relies on the generation of a high + concentration of H ions that are transported into the lumen of the gland. This process is fa- + + cilitated by activation of the gastric H ,K -ATPase, which translocates to the apical pole of + - the parietal cell. K as well as ATP hydrolysis and Cl all play critical roles in the activation + + of gastric H ,K -ATPase and are essential for the functioning of the enzyme (Reenstra and Forte 1990). This review will examine the classical proteins that have been linked to acid secretion as well as some recently identi?ed proteins that may modulate gastric acid secretion, in - dition we discuss the known secretagogues, and their receptors including a new receptor, which upon stimulation can lead to acid secretion.

The diverse roles of J-proteins, the obligate Hsp70 co-chaperone.- Role of the Mediator complex in nuclear hormone receptor signaling.- An update on acid secretion.- Structure-function relationship of the TRP channel superfamily.

Erscheint lt. Verlag	19.10.2010
Reihe/Serie	Reviews of Physiology, Biochemistry and Pharmacology
Zusatzinfo	IV, 90 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	153 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
Themenwelt	Naturwissenschaften ► Biologie
Schlagworte	Cells • Gastric gland • H,KATPase • J-protein • lead • Molecular Chaperones • Physiology • RNA polymerase II • Thyroid hormone receptor associated protein • Transient receptor potential • TRP channels cation channels
ISBN-10	3-642-06824-3 / 3642068243
ISBN-13	978-3-642-06824-9 / 9783642068249
Zustand	Neuware