Vanilloid Receptor TRPV1 in Drug Discovery – ing Pain and Other Pathological Disorders

Arthur Gomtsyan, Connie R. Faltynek (Herausgeber)

Software / Digital Media

480 Seiten

2010
Wiley-Blackwell (Hersteller)
978-0-470-58828-4 (ISBN)

Infos

This book discusses recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of transient receptor potential vanilloid subtype 1 (TRPV1) drug discovery research. Chapters explore the impact and drug targeting of TRPV1 in inflammation, migraine, arthritis, and cancer; as well as the development of analgesic drugs. The TRPV1 receptor is not limited to pain only, and the book covers its role in chronic cough, bladder disorders, and asthma. The book features data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designing TRPV1 antagonists.

Autor

ARTHUR GOMTSYAN is an Associate Research Fellow at Abbott Laboratories where he focuses on neuroscience research and pain drug targets. He is on the editorial board of two peer-reviewed journals and has over forty scientific articles to his credit. CONNIE R. FALTYNEK is a Director for Neuroscience and Pain Discovery at Abbott Laboratories. She has twenty years' experience in drug discovery research in the pharmaceutical industry and has published nearly 100 scientific papers.

Inhalt

Preface and Acknowledgments. Foreword. Contributors. PART I INTRODUCTION TO THE TRP CHANNELS. 1 TRP Channels and Human Diseases ( Bernd Nilius and Rudi Vennekens ). 2 Role of TRP Channels in Pain: An Overview ( Arpad Szallasi ). 3 Biochemical Pharmacology of TRPV1: Molecular Integrator of Pain Signals ( Carol S. Surowy, Philip R. Kym, and Regina M. Reilly ). 4 TRPV1 Genetics ( Ruslan Dorfman, Hubert Tsui, Michael W. Salter, and H.-Michael Dosch ). PART II ROLE FOR TRPV1 IN PAIN STATES. 5 TRPV1 and Inflammatory Pain ( Anindya Bhattacharya, Sonya G. Lehto, and Narender R. Gavva ). 6 Role of TRPV1 Receptors in Osteoarthritic Pain ( Shailen K. Joshi and Prisca Honore ). 7 TRPV1 and Bone Cancer Pain ( Juan Miguel Jimenez-Andrade and Patrick Mantyh ). 8 TRPV1 in Visceral Pain and Other Visceral Disorders ( Antonio Avelino and Francisco Cruz ). 9 TRPV1 Receptors and Migraine ( Philip R. Holland and Peter J. Goadsby ). 10 TRPV1 in Neuropathic Pain and Neurological and Neuropsychiatric Disorders ( Enza Palazzo, Katarzyna Starowicz, Sabatino Maione, and Vincenzo Di Marzo ). PART III TRPV1 ANTAGONISTS AND AGONISTS AS NOVEL ANALGESIC DRUGS. 11 Aryl-Urea Class and Related TRPV1 Antagonists ( Arthur Gomtsyan ). 12 2-Pyridinylpiperazine Carboxamide Class and Related TRPV1 Antagonists ( Natalie A. Hawryluk and Nicholas I. Carruthers ). 13 TRPV1 Agonist Approaches for Pain Management ( Keith R. Bley ). PART IV ROLE FOR TRPV1 IN OTHER PHYSIOLOGICAL PROCESSES BESIDES PAIN TRANSMISSION. 14 The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools? ( Andras Garami, Maria C. Almeida, Tatiane B. Nucci, Tamara Hew-Butler, Renato N. Soriano, Eszter Pakai, Kazuhiro Nakamura, Shaun F. Morrison, and Andrej A. Romanovsky ). 15 The Role of TRPV1 in Respiratory Diseases ( Serena Materazzi, Alain Tchoimou, Romina Nassini, Marcello Trevisani, and Pierangelo Geppetti ). 16 The Role of TRPV1 in Diabetes ( Hubert Tsui, Ruslan Dorfman, Michael W. Salter, and H.-Michael Dosch ). Afterword. Index.

Produkt-Details

• Erscheint lt. Verlag: 24.2.2010
• Verlagsort: Hoboken
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie
• ISBN-10: 0-470-58828-4 / 0470588284
• ISBN-13: 978-0-470-58828-4 / 9780470588284
• Zustand: Neuware