Cytoskeleton
Nova Science Publishers Inc (Verlag)
978-1-60876-559-1 (ISBN)
In this book, the authors review the effects of uPAR on the actin, intermediate filaments and microtubules that constitute the cell cytoskeleton, and the mechanisms used by uPAR to modulate intracellular signalling and temporally fine tune cytoskeletal dynamics. The effects of cytoskeletal components of uPAR expression and cellular distribution are examined as well. In addition, Duchenne Muscular Dystrophy (DMD) is an inherited disorder characterised by progressive muscular degeneration and cognitive impairment due to mutations in the DMD gene. Elucidation of the molecular basis for this illness has determined that cytoskeleton and the product of the DMD gene called dystrophin work in a co-ordinated way to maintain fibre muscle integrity. The authors describe the scientific path that allows elucidation of the molecular basis of DMD. Furthermore, cell motility is central to many aspects of cell, tissue, and organ function in both health and disease. Some of the more popular published experimental approaches to study cell motility are discussed. Also examined are the IQGAP family of proteins, which are now known to act at the interface between cellular signalling pathways and the actin cytoskeleton.
Preface; Follow the Leader: When the Urokinase Receptor Coordinates Cell Adhesion, Motility & Proliferation with Cytoskeleton Organization; LIMK 1, The Key Enzyme of Actin Remodeling Bridges Spatial Organization of Nucleus & Neural Transmission: From Heterochromatin Via Non-Coding RNAs to Complex Behavior; Common Tasks of Cytoskeleton & Dystrophin in Muscular & Neurological Functions: Perspectives in Gene Therapy; Measuring Reciprocal Regulation of Mesenchymal Stem Cell & Tumor Cell Motility in Two & Three Dimensions In Vitro; Centriole Duplication or DNA Replication: What Starts Earlier?; The Myosin Light Chain-IQGAP Interaction: What is its Function?; Migrating Plant Cell: F-Actin Asymmetry Directed by Phosphoinositide Signaling ; Membrane Microdomains & Neural Impulse Propagation: Field Effects in Cytoskeleton Corrals ; Scaffolding Proteins that Regulate the Actin Cytoskeleton in Cell Movement ; Index.
| Erscheint lt. Verlag | 17.9.2010 |
|---|---|
| Zusatzinfo | Illustrations, unspecified |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 260 x 180 mm |
| Gewicht | 654 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Zellbiologie |
| ISBN-10 | 1-60876-559-8 / 1608765598 |
| ISBN-13 | 978-1-60876-559-1 / 9781608765591 |
| Zustand | Neuware |
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