Cytochrome P450

Structure, Mechanism and Biochemistry

Paul R.Ortiz de Montellano (Herausgeber)

Buch | Hardcover

652 Seiten

1995 | 2nd ed. 1995
Plenum Publishing Co.,N.Y. (Verlag)
978-0-306-45141-6 (ISBN)

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In the ten years that have elapsed since the first edition of this book went to press, the cytochrome P450 field has completed the transition to a discipline in which structure and mechanism, even regulation and biological function, are dealt with in molecular terms. The twin forces that have propelled this remarkable progress have been the widespread adoption of molecular biological approaches and the successful application of modem structural techniques. Only a few P450 primary sequences were available in 1985, whereas hundreds of P450 sequences are now available. Site-specific mutagenesis was then mostly a proverbial gleam in the eye of the P450 community, but it is now a standard technique in the research repertoire. The first crystal structure of a cytochrome P450 enzyme had just been solved in 1985 and appeared on the cover of the first edition. Today, the high-reso- lution crystal structures of four soluble bacterial P450 enzymes are available and the race is on to develop approaches that will permit us to determine the structures of the membrane-bound forms of the enzyme.
The past ten years has seen phenomenal progress- let us hope that the next ten will prove equally exciting. The book is informally divided into four sections. In order to hold the book close to the advancing front of research, some of the chapter topics from the first edition have been dropped to make room for new or expanded topics.

Recent Work: Models and Mechanisms of Cytochrome P450 Action (J.T. Groves, Y. Han). Comparison of the Peroxidase Activity of Hemoproteins and Cytochrome P450 (L.J. Marnett, T.A. Kennedy). Structurally Defined Bacterial Enzymes: Twentyfive Years of P450cam Research: Mechanistic Insights into Oxygenase Catalysis (E.J. Mueller et al.). Structural Studies on Prokaryotic Cytochromes P450 (T.L. Poulos et al.). Bacterial P450s: Structural Similarities and Functional Differences (J.A. Peterson, S.E. GrahamLorence). Structures and Mechanisms of Membranebound P450 Enzymes: Structures of Eukaryotic Cytochrome P450 Enzymes (C. von Wachenfeldt, E.F. Johnson). NADPH Cytochrome P450 Reductase and Its Structural and Functional Domains (H.W. Strobel et al.). Oxygen Activation and Reactivity (P.R. Ortiz de Montellano). Inhibition of Cytochrome P450 Enzymes (P.R. Ortiz de Montellano, M.A. Correia). Regulatory Mechanisms and Physiological Roles of Cytochrome P450: Induction of Cytochrome P450 Enzymes That Metabolize Xenobiotics (J.P. Whitlock, Jr., M.S. Denison). Hormonal Regulation of Liver Cytochrome P450 Enzymes (D.J. Waxman, K.H. Chang). Regulation of Steroidogenic and Related P450s (N. Kagawa, M.R. Waterman). Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids (J.H. Capdevila et al.). Human Cytochrome P450 Enzymes (F.P. Guengerich). Heme Thiolate Proteins Different from Cytochromes P450 Catalyzing Monooxygenations (D. Mansuy, J.P. Renaud). Appendixes. Index.

`This new edition lives up to the high standards of the first and should quickly become a standard reference for experts while providing a logical starting point for newcomers to the field.' Science

Erscheint lt. Verlag	31.10.1995
Zusatzinfo	biography
Verlagsort	Boston
Sprache	englisch
Maße	152 x 229 mm
Gewicht	1223 g
Einbandart	gebunden
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	0-306-45141-7 / 0306451417
ISBN-13	978-0-306-45141-6 / 9780306451416
Zustand	Neuware