Drug-DNA Interaction Protocols
Humana Press Inc. (Verlag)
978-1-60327-417-3 (ISBN)
Quantitative Analysis of Small Molecule–Nucleic Acid Interactions with a Biosensor Surface and Surface Plasmon Resonance Detection.- Thermal Melting Studies of Ligand DNA Interactions.- Circular and Linear Dichroism of Drug-DNA Systems.- Drug Binding to DNA?RNA Hybrid Structures.- Quantification of Binding Data Using Capillary Electrophoresis.- Determination of Equilibrium Association Constants of Ligand–DNA Complexes by Electrospray Mass Spectrometry.- Detection of Adriamycin-DNA Adducts by Accelerator Mass Spectrometry.- Molecular Modelling Methods to Quantitate Drug-DNA Interactions.- Application of Anomalous Diffraction Methods to the Study of DNA and DNA-Complexes.- DNase I Footprinting.- Methods to Characterize the Effect of DNA-Modifying Compounds on Nucleosomal DNA.- REPSA: Combinatorial Approach for Identifying Preferred Drug-DNA Binding Sequences.- In vitro Transcription Assay for Resolution of Drug-DNA Interactions at Defined DNA Sequences.- In vitro Footprinting of Promoter Regions Within Supercoiled Plasmid DNA.- Topoisomerase I-Mediated DNA Relaxation as a Tool to Study Intercalation of Small Molecules into Supercoiled DNA.- A High-Throughput Assay for DNA Topoisomerases and Other Enzymes, Based on DNA Triplex Formation.- Measurement of DNA Interstrand Crosslinking in Individual Cells Using the Single Cell Gel Electrophoresis (Comet) Assay.- Measurement of DNA Interstrand Crosslinking in Naked DNA Using Gel-Based Methods.- An Evaluation Cascade for G-Quadruplex Telomere Targeting Agents in Human Cancer Cells.
Erscheint lt. Verlag | 17.12.2009 |
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Reihe/Serie | Methods in Molecular Biology ; 613 |
Zusatzinfo | 1 Illustrations, color; 102 Illustrations, black and white; IX, 311 p. 103 illus., 1 illus. in color. |
Verlagsort | Totowa, NJ |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
Medizin / Pharmazie ► Pharmazie | |
Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
ISBN-10 | 1-60327-417-0 / 1603274170 |
ISBN-13 | 978-1-60327-417-3 / 9781603274173 |
Zustand | Neuware |
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