Signaling by Toll-Like Receptors
Seiten
2008
Crc Press Inc (Verlag)
978-1-4200-4318-1 (ISBN)
Crc Press Inc (Verlag)
978-1-4200-4318-1 (ISBN)
Presents a review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors, as well as the promise for uncovering effective pharmaceutical targets.
The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.
The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.
Gregory W. Konat
Assessing the Response of Cells to TLR Stimulation. TLR Ligands in Experimental Settings: Their Purity and Specificity. Analysis of TLR Expression, Regulation, and Signaling. Intracellular Trafficking of Toll-Like Receptors. The Role of Small RhoGTPases in TLR Signaling. Use of Engineered β-Lactamase Fragment Complementation to Detect the Associations of Toll-Like Receptors and Signaling Adaptors. Use of Toll-Like Receptor Chimeras to Dissect Mechanisms of Receptor Localization and Signaling. Engagement of Toll-Like Receptors Modulates Chemokine Receptor Signaling. Role of Toll-Like Receptor Signaling in Central Nervous System Infections. The Influence of Injury on Toll-Like Receptor Responses. Index.
| Verlagsort | Bosa Roca |
|---|---|
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 453 g |
| Themenwelt | Studium ► Querschnittsbereiche ► Infektiologie / Immunologie |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| ISBN-10 | 1-4200-4318-8 / 1420043188 |
| ISBN-13 | 978-1-4200-4318-1 / 9781420043181 |
| Zustand | Neuware |
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