Novel Inhibitors of Leukotrienes

Giancarlo Folco, Bengt Samuelsson, Robert C. Murphy (Herausgeber)

Buch | Hardcover

XII, 347 Seiten

1999 | 1999
Springer Basel (Verlag)
978-3-7643-5884-6 (ISBN)

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Many new antileukotriene drugs are now marketed as antiasthma drugs andrepresent the first new drugs in this field since the 1970s. This bookcovers the steps that have led to the discovery and development of thesenew drugs and offers detailed descriptions of their clinicalapplications. The review chapters on the main aspects of basic andapplied leukotriene research are written by leading specialists in thefield, and the volume takes a new approach in presenting information ofparticular interest to both scientists and clinicians in the fields ofasthma, inflammation and allergic diseases.

5-Lipoxygenase.- LTC4 synthase: A key enzyme in cysteinyl leukotriene formation.- Leukotriene A4 hydrolase: A key enzyme in chemotactic leukotriene formation.- Metabolism of leukotrienes and formation of new leukotriene structures.- Receptors for cysteinyl-leukotrienes: Targets for new drugs.- Targeted disruption of 5-lipoxygenase.- Transcellular biosynthesis of leukotrienes: A unique mode of cell communication.- Physiological and pathophysiological activities of leukotrienes.- Entry rate and metabolic handling of LTC4 in the human circulation.- Genetic polymorphisms of 5-LO.- Leukotrienes and aspirin-intolerant asthma.- Leukotrienes in nocturnal asthma.- Leukotrienes and allergic asthma.- Inhibitors of leukotrienes: An overview.- The development of zafirlukast (Accolate®) and the Zeneca series of peptidyl-leukotriene receptor antagonists.- The development of zileuton (ZYFLO®) and the N-hydroxyurea class of 5-lipoxygenase inhibitors.- The development of BAY X 1005 and the Bayer series of leukotriene biosynthesis inhibitors.- The development of iralukast: A member of the Novartis series of cysteinyl leukotriene antagonists.- LTB4 receptor antagonists.- SmithKline Beecham pharmaceuticals' cysteinyl leukotriene receptor antagonists: Pranlukast (SB 205312; Ono-1078; Onon), Pobilukast (SK&F 104353) and SK&F 106203.

Erscheint lt. Verlag	1.9.1999
Reihe/Serie	Progress in Inflammation Research
Zusatzinfo	XII, 347 p.
Verlagsort	Basel
Sprache	englisch
Maße	155 x 235 mm
Gewicht	1510 g
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
Schlagworte	Asthma • Cell • Development • Diseases • Drugs • inflammation • Metabolism • Pharmaceutical • Research
ISBN-10	3-7643-5884-X / 376435884X
ISBN-13	978-3-7643-5884-6 / 9783764358846
Zustand	Neuware