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Cellular Respiration and Carcinogenesis

Shireesh Apte, Rangaprasad Sarangarajan (Herausgeber)

Buch | Hardcover

195 Seiten

2008
Humana Press Inc. (Verlag)
978-1-934115-07-7 (ISBN)

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Cellular Respiration and Carcinogenesis presents leading experts in the field as it informs the reader about both basic and recent research in the field of cellular respiration and the effects of its dysfunction, alteration or attenuation on the development of cancer. This masterfully compiled text offers the reader a fundamental understanding about how oxygen sensing and/or availability, programmed cell death, immune recognition and response and glucose metabolism are intimately linked with the two major mechanism or pathways of cellular respiration; oxidative phosphorylation and glycolysis. The editors and contributing authors proficiently and unequivocally address the effects of dysfunction of the mitochondrial oxidative phosphorylation/glycolysis (cellular respiration) mechanisms and pathways on the development of cancer. While it remains true that there are no universal truths in cancer, Cellular Respiration and Carcinogenesis opens the dialogue that the etiology of cancer can usually be associated with, and significantly attributed to the failure of one or multiple pathways of oxidative phosphorylation (cellular respiration) to normally burn fuel to generate energy, vis-à-vis the Warburg hypothesis. Keeping with its cutting-edge nature, Cellular Respiration and Carcinogenesis provides the first glimpse to a cautionary evidence based counterbalance to the recent and rapidly proliferating notion that utilization of fuel primarily via glycolysis is a hallmark of cancer development.

Oxidative Phosphorylation and Cancer: The Ongoing Warburg Hypothesis.- The Electron Transport Chain and Carcinogenesis.- Respiratory Control of Redox Signaling and Cancer.- Cellular Respiration and Dedifferentiation.- Cellular Adaptations to Oxidative Phosphorylation Defects in Cancer.- Regulation of Glucose and Energy Metabolism in Cancer Cells by Hypoxia Inducible Factor 1.- The Role of Glycolysis in Cellular Immortalization.- Metabolic Modulation of Carcinogenesis.- Mitochondrial DNA Mutations in Tumors.- Cellular Respiration and Tumor Suppressor Genes.- Uncoupling Cellular Respiration: A Link to Cancer Cell Metabolism and Immune Privilege.- How Cancer Cells Escape Death.

Erscheint lt. Verlag	11.11.2008
Zusatzinfo	XI, 195 p.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	1-934115-07-X / 193411507X
ISBN-13	978-1-934115-07-7 / 9781934115077
Zustand	Neuware