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Transport in the Liver

Buch | Hardcover

272 Seiten

1994 | 1994 ed.
Springer (Verlag)
978-0-7923-8858-6 (ISBN)

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Important functions of the liver are controlled by transport across different membrane domains. Advances in molecular cell biology have contributed to a better understanding of transport mechanisms in hepatocytes. The chapters in this book, the proceedings of the 74th Falk Symposium held in Heidelberg, Germany, 27--28 January 1994, discuss the current concepts in transport of low molecular weight substances across the sinusoidal membrane, intracellular events in conjugation and transport, as well as export across the canalicular hepatocyte membrane.
Transport processes are discussed on the level of the carrier molecules, on the cellular level, as well as in the intact organ. In addition, the regulation of transport systems is addressed. An invaluable contribution to the exchange of information between basic scientists and clinical hepatologists in the rapidly expanding area of membrane transport.

Preface. Section I: Concepts in Hepatic Transport. 1. Mechanisms in membrane transport; G. Burckhardt. 2. Physiological utility of biliary secretion and excretion; A.F. Hofmann. 3. Regulation of transport across hepatocyte membranes -- determinants of bile formation; J.L. Boyer. 4. Molecular properties of two basolateral bile acid and organic anion transporters of rat and human liver; P.J. Meier, B. Hagenbuch, B. Stieger, G. Kullak-Ublick, E. Jacquemin. Section II: Uptake Across the Hepatocyte Sinusoidal Membrane. 5. Molecular cloning and expression of a human cDNA encoding system ASC amino acid transport activity; M.S. Kilberg, B.K. Tamarappoo, S. Shafgat, R.T. Fremeau Jr. 6. Glucose transport across hepatic membranes; A. Burchell. 7. Mechanism of cellular fatty acid uptake: a 1994 update; W. Stremmel, B.A. Fitscher, C. Elsing, U. Winn-Börner, J. Gunawan, H. Kleinert, K. Vogelsang, A. Kassner, K. Möller, M. Schürer. 8. Transport of conjugated and unconjugated bile salts across the sinusoidal membrane; W. Gerok, G. Kurz, D. Schwab. Section III: Intracellular Events in Conjugation and Transport. 9. Cellular hydration and bile acid secretion in the isolated perfused rat liver; D. Häussinger. 10. Intracellular vesicles and the transport of organic anions; R.P.J. Oude Elferink, H. Roelofsen, C. Bakker, R. Ottenhoff, M. Heijn. 11. A transport system for glutathione in rat liver endoplasmic reticulum; H.-D. Söling, A. Weilandt, A. Wasmuth. 12. Hepatic glutathione conjugation and membrane-bound glutathione S-transferase activities; T.P.M. Akerboom, M.E. Horbach, H. Sies. Section IV: Transport Across the Hepatocyte Canalicular Membrane. 13. Canalicular ecto-ATPase and ATP-dependent transport; I.M. Arias, D. Ortiz, C. Leveille-Webster, M. Che, M. St-Pierre, J.F. Dufour, Z. Gatmaitan. 14. ATP-dependent transport of amphiphilic cations across the canalicular membrane mediated by P-glycoprotein; M. Muller. 15. Mechanisms of canalicular GSH secretion; N. Kaplowitz, J.C. Fernández-Checa, J-R Yi. 16. Expression of canalicular bile salt transporters; F.J. Suchy. 17. Cholestasis resulting from inhibition of the ATP-dependent bile salt export carrier by cyclosporins; M. Böhme, I. Leier, G. Jedlitschky, D. Keppler. 18. Mechanisms of intrahepatic cholestasis; H. Takikawa, N. Sano, Y. Wako, M. Fujiyoshi, M. Yamanaka. Section V: Multidrug Resistance Gene Products and ATP-Dependent Transport Across the Canalicular Membrane. 19. Structure and function of P-glycoprotein transporter; M.M. Gottesman. 20. The physiological role of mdr2 P-glycoprotein in hepatobiliary phospholipid transport; R.P.J. Oude Elferink, J.J.M. Smit, A.H. Schinkel, R. Ottenhoff, M. van Wijland, G.J.A. Offerhaus, P. Borst, A.K. Groen. 21. Regulation of the multidrug resistance genes in the rat liver; J.A. Silverman, B.A. Hill, P.A. Brown, K.H. Preisegger, T.W. Gant. 22. Substrates for P-glycoprotein in kidney; R. Hori, Y. Tanigawara, M. Hirai, M. Yasuhara, K. Ueda, T. Komano. 23. P-glycoprotein expression in normal and transformed hepatocyte cultures; O. Fardel, V. Lecureur, A. Guillouzo. 24. Induction of multidrug resistance gene products in cholestasis; D. Schrenk, T.W. Gant, H.-H. Preisegger, J.A. Silverman, S.S. Thorgeirsson. Index.

Reihe/Serie	Falk Symposium ; 74
Zusatzinfo	272 p.
Verlagsort	Dordrecht
Sprache	englisch
Gewicht	601 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Hepatologie
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
ISBN-10	0-7923-8858-5 / 0792388585
ISBN-13	978-0-7923-8858-6 / 9780792388586
Zustand	Neuware