Statistical Genetics

Gene Mapping Through Linkage and Association

Benjamin Neale, Manuel Ferreira, Sarah Medland, Danielle Posthuma (Herausgeber)

Buch | Softcover

606 Seiten

2007
Taylor & Francis Ltd (Verlag)
978-0-415-41040-3 (ISBN)

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Statistical Genetics focuses on conducting genetic linkage and association analysis in the post-genomic era. It covers established and new methodologies, providing the genetic and statistical theory on which they are based. Worked examples of important methods are given, as well as study design and sources of error.

Statistical Genetics is an advanced textbook focusing on conducting genome-wide linkage and association analysis in order to identify the genes responsible for complex behaviors and diseases. Starting with an introductory section on statistics and quantitative genetics, it covers both established and new methodologies, providing the genetic and statistical theory on which they are based. Each chapter is written by leading researchers, who give the reader the benefit of their experience with worked examples, study design, and sources of error.

The text can be used in conjunction with an associated website (www.genemapping.org) that provides supplementary material and links to downloadable software.

Neale, Benjamin; Ferreira, Manuel ; Medland, Sarah; Posthuma, Danielle

1. Introduction 2. DNA 3. Introduction to Biometrical Genetics 4. Introduction to Statistics 5. Statistical Power 6. Population Genetics and its Relevance to Gene Mapping 7. Principles of Linkage Analysis 8. IBD Estimation 9. Regression Methods for Linkage Analysis 10. Variance Components Linkage Analysis for Quantitative Traits 11. Extensions to Univariate Linkage Analysis 12. QTL Detection in Multivariate Data from Sibling Pairs 13. Factors Affecting Type I Error and Power of Linkage Analysis 14. Introduction to Association 15. Single-locus Association Models 16. Genome-wide Association 17. Haplotype Estimation 18. Multi-locus Association Models 19. Linkage Disequilibrium and Tagging 20. Haploview 21. Factors Affecting Type I Error and Power in Association 22. Resampling Approaches to Statistical Interference

Erscheint lt. Verlag	6.12.2007
Zusatzinfo	150 Tables, black and white; 55 Line drawings, black and white; 5 Halftones, color; 4 Halftones, black and white
Verlagsort	London
Sprache	englisch
Maße	174 x 246 mm
Gewicht	1120 g
Themenwelt	Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	0-415-41040-1 / 0415410401
ISBN-13	978-0-415-41040-3 / 9780415410403
Zustand	Neuware