Transfusion and Hematopoietic Stem Cell
Blackwell Science Ltd (Verlag)
978-0-86542-911-6 (ISBN)
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The use of haematopoietic stem cells in transfusion medicine is radically changing the current treatment protocols for cancer and haematological disorders. This book provides a description of the current research behind bone marrow, cord and peripheral blood stem cell transplantation, covering its possible clinical uses and techniques for collection, characterization and in-vivo and in-vitro properties of haematopoietic stem cells. This title records the proceeding of the 6th Hokkaido Symposium on Transplantation Medicine, and reviews the current status of this field of medicine for oncologists, haematologists and bone marrow transplantation specialists.
Introduction: the role of blood centers for haematopoetic stem cell transplantation. Part 1 Bone marrow and peripheral blood stem cell transplantation: current status of allogeneic bone marrow transplantation in Japan; collection and transplant of peripheral blood stem cells in children; peripheral blood stem cell transplantation for the treatment of haematologic malignancy; peripheral blood stem cell transplantation for the treatment of solid tumours; kinetics of peripheral blood stem cell collection and transplantation. Part 2 Efficient collection of peripheral blood stem cells: therapy-orientated strategies in collecting peripheral blood stem cells (PBSC); peripheral blood stem cell collection with multi-component apheresis system MCS-3p. Part 3 Characterization of haematopoietic stem cells in bone marrow, peripheral blood and umbilical cord blood: different responses of human marrow, peripheral blood and cord blood haemotopoietic progenitors of cytokines; purification of CD34-positive cells from umbilical cord blood; characterization of marrow, blood and umbilical cord-derived stem cells after cryopreservation; expression of adhesion molecules on human haematopoietic progenitor cells; purification and characterization of haematopoietic stem cells in cord blood. Part 4 Signal transduction in stem cells: signal transduction in stem cells. Part 5 Placenta blood stem cell transplantation: placenta/umbilical cord blood stem cells for narrow reconstitution in man. Part 6 Regulation of stem cell differentiation: differentiation and proliferation of murine lymphohemopoietic progenitors. Part 7 In vivo expansion of haematopoietic stem cells: peripheral blood stem cell transplantation - the UCLH experience; autologous, syngeneic, and allogeneic transplantation of peripheral blood stem cells; expression of adhesion molecules on haematopoietic progenitor cells mobilized by G-CSF; in vivo expansion of peripheral blood stem cells by injection of rhG-CSF in healthy volunteer donors; High-dose chemotherapy with thiotepa mitoxantrone and cyclophosphamide (TMC), with autologous progenitor cell support in the treatment of breast cancer. Part 8 In vitro expansion of haematopoietic stem cells: signal transduction in stem cell proliferation haematopoietic reconstitution of murine haematopoietic progenitor cells expanded in vitro; in vitro expansion of human peripheral blood CD43+ cells and transitional change of proliferative and differentiative capacity. Part 9 Umbilical cord blood stem cells: isolation, expansion and transplantation; methods of cell sedation using monoclonal antibodies selection and transplantation of CD34+ cells using the isolex immunomagnetic cell separation systems; autologous bone marrow transplantation using positive selection of human haematopoietic progenitor cells in the treatment of breast cancer; mobilization, separation and expansion of peripheral blood progenitor cells; in vitro expansion of cord blood. (Part contents)
| Erscheint lt. Verlag | 27.8.1996 |
|---|---|
| Zusatzinfo | 54 illustrations, index |
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 172 x 244 mm |
| Gewicht | 745 g |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Hämatologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie | |
| ISBN-10 | 0-86542-911-1 / 0865429111 |
| ISBN-13 | 978-0-86542-911-6 / 9780865429116 |
| Zustand | Neuware |
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