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Radiation Oncology Advances

Søren M. Bentzen, Paul M. Harari, T. Rockwell Mackie, Minesh P. Mehta (Herausgeber)

Buch | Hardcover

336 Seiten

2007
Springer-Verlag New York Inc.
978-0-387-36743-9 (ISBN)

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from combining radiation with a molecular targeted agent – namely cetuximab, a recombinant mouse/human chimeric monoclonal antibody against the Epidermal Growth Factor (EGF) receptor [4] Astsaturov, Cohen and Harari present a more indepth review of the biology of the EGF Receptor and its signaling pathway in Chap. 7 as a potential target in combination with fractionated radiotherap y for head and neck squamous cell carcinoma (HNSCC). A flurry of agents are under de velopment for targeting EGFR and in March 2006, the US Food and Drugs Administration approved cetuximab combined with radiation as a primary treatment option for patients with loco-regionally advanced HNSCC in whom chemoradiation therapy is deemed not to be an option. While blocking the EGF pathway during fractionated radiotherapy may seem an obvious strategy [5], the rationale for combining antiangiogenic and antivascular targeting agents with radiation may be less intuitive. However, recent research shows that there are several reasons why this could result in a therapeutic gain in practice. Chapter 8 is a review of this rapidly expanding field by Citrin and Camphausen. Targeted agents combined with radiation may offer new opportunities in the treatment of central nervous system malignancies, a tumor type where the outlook remains poor despite some recent progress [6]. Current attempts to overcome rad- tion resistance in these tumors on the basis of an improved understanding of their molecular biology are the topic of Chap. 9 by Chakravarti and Palanichamy.

Advances in Imaging and Biologically-Based Treatment Planning.- Radiation Oncology Advances: An Introduction.- Advanced Image-Guided External Beam Radiotherapy.- Dose Painting and Theragnostic Imaging: Towards the Prescription, Planning and Delivery of Biologically Targeted Dose Distributions in External Beam Radiation Oncology.- Molecular and Functional Imaging in Radiation Oncology.- Prognostic and Predictive Markers in Radiation Therapy: Focus on Prostate Cancer.- Advances in Molecular Biology and Targeted Therapies.- Overview of Cancer Molecular Radiobiology.- Clinical Application of EGFR Inhibitors in Head and Neck Squamous Cell Cancer.- Advancement of Antiangiogenic and Vascular Disrupting Agents Combined with Radiation.- Overcoming Therapeutic Resistance in Malignant Gliomas: Current Practices and Future Directions.- Advances in Treatment Delivery and Planning.- Advances in Intensity-Modulated Radiotherapy Delivery.- Image-Based Modeling of Normal Tissue Complication Probability for Radiation Therapy.- Optimization of Radiotherapy Using Biological Parameters.- Clinical Advances.- Combined Chemoradiotherapy Advances.- Cytoprotection for Radiation-Associated Normal Tissue Injury.

Reihe/Serie	Cancer Treatment and Research ; 139
Zusatzinfo	XVI, 336 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Themenwelt	Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie
ISBN-10	0-387-36743-8 / 0387367438
ISBN-13	978-0-387-36743-9 / 9780387367439
Zustand	Neuware