The Foundations of Immunology and their Pertinence to Medical Interventions

Peter Bretscher (Autor)

Buch | Hardcover

216 Seiten

2024 | Unabridged edition
Cambridge Scholars Publishing (Verlag)
978-1-0364-1257-9 (ISBN)

Noch nicht erschienen (ca. November 2024)
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This book provides a history of the foundational concepts of immunology and recognizes the central role of paradoxes, and their resolution, in advancing the canon. It identifies many paradoxes in the context of the contemporary, dominant frameworks employed by researchers in the last few decades to analyse how immune responses are regulated. The foundational ideas proposed resolve these paradoxes. The resulting framework emerges as a powerful platform for elucidating common immune mechanisms and proposing strategies to prevent and treat autoimmunity, cancer and certain problematical infectious diseases, such as AIDS and tuberculosis. This holistic approach underscores the significance of fundamental immunological principles, showcasing the potential of the framework to revolutionize immunotherapy and disease management. The focus on paradoxes and their resolution results in a short, jargon-free text, accessible to the engaged general reader, and provides a platform for researchers to debate central issues of the field. This book illustrates how the recognition and resolution of paradoxes can transcend the challenges posed by the information overload.

Peter Bretscher is known for his theoretical and experimental contributions to immunology. His 1970 Science article with Melvin Cohn, proposed the Two-Signal Model of lymphocyte activation. Their theory explained how self-nonself discrimination is achieved and has become part of the canon of the field. Peter became fascinated by immunology during his PhD studies in Molecular Biology in the mid-1960s. He was fortunate to be able to discuss ideas with Francis Crick, who gave young Peter guidance. In the 1970s, Peter also proposed how the class of immunity is controlled. This led for the first time to a basically conceived strategy of vaccination against pathogens uniquely susceptible to cell-mediated attack, such as those causing AIDS and tuberculosis. His laboratory reported the successful testing of this strategy in a 1991 Science article. Peter still explores how basic mechanisms by which immunity is controlled can provide a platform for immunotherapy and disease management.

Erscheint lt. Verlag	1.11.2024
Verlagsort	Newcastle upon Tyne
Sprache	englisch
Maße	148 x 212 mm
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
ISBN-10	1-0364-1257-1 / 1036412571
ISBN-13	978-1-0364-1257-9 / 9781036412579
Zustand	Neuware