Studies in Osteoarthrosis
John Wiley & Sons Ltd (Verlag)
978-0-471-91336-8 (ISBN)
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Current treatment of this common crippling disease depends primarily on non-steroidal anti-inflammatory drugs (NSAIDS) which are more effective and better tolerated than simple analgesics. There is considerable concern however regarding long term therapy and development of symptoms such as charcot-like joints on some patients which contradict impressive symptomatic improvement in others. Clinicians need to know why and understand more of the underlying processes, both clinical and biochemical aspects. This book presents a collection of well illustrated anatomical and biochemical studies to show where future progress may be made. NSAIDS are shown, using animal models, to have significant effects on many processes protective or destructive, involved in cartilage degeneration. Intervention of these processes leads to progressive studies including pathogenesis in animal models, the role of anti- inflammatory drugs in bone destruction and pharmacological control. Lastly, the value of methods available for assessing changes or benefits of such intervention is considered.
Processes at Work in OA; Clinical Aspects of Osteoarthritis; Anatomical Changes and Pathogenesis of OA in Man, with Particular Reference to the Hip and Knee Joints; Biochemical Changes in Human Osteoarthrotic Cartilage; On the Pathogenesis of Canine Osteoarthritis; Cellular Changes in Synovium and Meniscus of a Rabbit Model of Osteoarthritis Induced by Partial Meniscectomy; Effects of Intervention on the Processes of OA; Osteoarthrosis-like Disease in Mice: Effects of Anti-arthrotic and Antirheumatic Agents; Effect of Selected Antirheumatic Agents on Surgically-induced Degenerative Knee Joint Disease in Rabbits; Bone Destruction in Osteoarthritis and the Possible Role of Anti- inflammatory Drugs; Towards Therapy for the Future: Testing in Cartilage-Synovium Co-cultures to Detect Potential Cartilage- protective Drugs; Pharmacological Control of Osteoarthritis: A Realisable Goal?; How Can Progression of OA be Measured in Man?; Clinical Assessment; Arthroscopy in the Assessment of the Progress of Osteoarthritis; Radiology Radioisotope Measurements
| Erscheint lt. Verlag | 29.4.1987 |
|---|---|
| Zusatzinfo | illustrations, bibliography, index |
| Verlagsort | Chichester |
| Sprache | englisch |
| Maße | 210 x 280 mm |
| Gewicht | 710 g |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie |
| ISBN-10 | 0-471-91336-7 / 0471913367 |
| ISBN-13 | 978-0-471-91336-8 / 9780471913368 |
| Zustand | Neuware |
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