A Beginner's Guide to Targeted Cancer Treatments and Cancer Immunotherapy
John Wiley & Sons Inc (Verlag)
978-1-119-83406-9 (ISBN)
An accessible guide written in everyday language for nurses and non-scientists
Written by gifted communicator Elaine Vickers, PhD, this is the second edition of her popular book, first published in 2018. Since then, hundreds of readers have benefited from Elaine's informal style, clear explanations, and wide knowledge of cancer biology and cancer treatments.
Now, with new chapters reflecting advancements in immunotherapy, every section has been updated to include the latest developments.
With the help of this book, readers will be ideally placed to understand the latest developments, equipping them with insights and explanations that will help them communicate with colleagues and patients.
Readers of the second edition of »A Beginner's Guide to Targeted Cancer Treatments and Cancer Immunotherapy« will also find:
- Over 100 updated and brand-new illustrations
- A wide-ranging introduction to cancer biology and the relationship between cancer and the immune system
- Why monoclonal antibodies and small molecules are so often used as cancer treatments
- Important insights into cell communication pathways as a common target
- Detailed discussion of immune checkpoint inhibitors
- An introduction to the science behind novel immunotherapies, such as CAR T cell therapy and T cell engagers
- An overview of relevant treatment targets for all major cancer types, including hematological cancers
- Explanations of each treatment's target, mechanism, limitations, and reasons for resistance
»A Beginner's Guide to Targeted Cancer Treatments and Cancer Immunotherapy« is a must-own for anyone involved in the treatment of cancer patients or working with related data.
This book is ideal for doctors, nurses, and other healthcare professionals wanting to grasp the scientific concepts that underpin the latest cancer treatments.
Elaine Vickers, PhD, is the Founder of Science Communicated Ltd., a company specializing in courses and educational materials for explaining cancer biology. Every year her teaching, in partnership with hospitals, charities, private companies, clinical trials units, and more reaches hundreds of nurses and professionals throughout the UK and beyond.
Acknowledgments ix
Praise for the First Edition xi
About the Author xiii
How to Use This Book xv
Chapter 1 An Introduction to Cancer Cell Biology and Genetics 1
1.1 Introduction 2
1.2 DNA Damage Is the Cause of Every Cancer 3
1.3 The Defining Features (Hallmarks) of Cancer Cells 18
1.4 Variation Among Cancer Cells in a Single Tumor 20
1.5 Cancer’s Relationship with Our Immune System 22
1.6 The Cancer Microenvironment 30
1.7 Cancer Spread/Metastasis 36
1.8 Cancer Stem Cells 39
1.9 Unique Properties of Hematological Cancers 40
1.10 Obstacles that Prevent Us from Curing Cancer 46
1.11 Final Thoughts 52
Chapter 2 Monoclonal Antibodies and Small Molecules as Cancer Treatments, 61
2.1 Introduction 62
2.2 Antibody-Based Cancer Treatments 66
2.3 Small Molecule Cancer Treatments 83
2.4 Treatment Combinations 99
2.5 Final Thoughts 100
Chapter 3 Treatments that Target Cell Communication 109
3.1 Introduction 110
3.2 Growth Factor-Controlled Signaling Pathways 112
3.3 Growth Factor Receptors in Cancer 118
3.4 Drugs that Target EGFR 121
3.5 Drugs that Target HER2 131
3.6 Drugs that Block Other Growth Factor Receptors 138
3.7 Targeting the MAPK Signaling Pathway 145
3.8 Targeting the PI3K/AKT/mTOR Signaling Pathway 156
3.9 Targeting the JAK-STAT Pathway 164
3.10 Bcr-Abl Inhibitors 167
3.11 Final Thoughts 169
Chapter 4 More Targets and Treatments 183
4.1 Angiogenesis Inhibitors 184
4.2 Antibody Conjugates 195
4.3 PARP Inhibitors 202
4.4 CDK Inhibitors and Other Cell Cycle-Targeted Treatments 211
4.5 Hedgehog Pathway Inhibitors 219
4.6 Targeting Epigenetic Enzymes 222
4.7 Targeting Cell Survival 226
4.8 Targeting B Cell Receptor Signaling 230
4.9 Nuclear Transport Inhibitors 235
4.10 Proteasome Inhibitors 236
4.11 Final Thoughts 240
Chapter 5 Immunotherapy with Checkpoint Inhibitors, 253
5.1 The Importance of T Cells 254
5.2 An Introduction to Immune Checkpoint Inhibitors 256
5.3 How Checkpoint Inhibitors Work 260
5.4 Lessons Learned from Checkpoint Inhibitor Trials 261
5.5 Why Some Patients Benefit from Checkpoint Inhibitors and Others Don’t 271
5.6 Biomarkers of Response to Checkpoint Inhibitors 275
5.7 Checkpoint Inhibitor Combinations 282
5.8 Novel Checkpoint Inhibitors and Activators 287
5.9 Final Thoughts 290
Chapter 6 Other Forms of Immunotherapy 301
6.1 Introduction 302
6.2 Naked Antibodies that Trigger an Immune Response 303
6.3 Immunomodulators and CELMoDs 304
6.4 Introduction to Adoptive Cell Therapies 307
6.5 Tumor‐Infiltrating Lymphocyte Therapy 308
6.6 CAR T Cell Therapy 312
6.7 TCR‐Engineered T Cell Therapy 326
6.8 Cell Therapy with Other White Blood Cells 331
6.9 T Cell Engagers 332
6.10 Cancer Treatment Vaccines 340
6.11 Final Thoughts 351
Chapter 7 Treatments Relevant to Individual Cancer Types 359
7.1 Introduction 359
7.2 Treatments for Breast Cancer 361
7.3 Treatments for Bowel and Anal Cancers 364
7.4 Treatments for Lung Cancer 367
7.5 Treatments for Prostate, Testicular, and Penile Cancers 371
7.6 Treatments for Head and Neck Cancer 374
7.7 Treatments for Esophageal, Gastroesophageal Junction, and Stomach Cancers 376
7.8 Treatments for Pancreatic, Bile Duct, and Primary Liver Cancers 378
7.9 Treatments for Kidney and Bladder Cancers 381
7.10 Treatments for Ovarian Cancer 383
7.11 Treatments for Other Gynaecological Cancers 384
7.12 Treatments for Brain and CNS Cancers 386
7.13 Treatments for Skin Cancer 388
7.14 Treatments for B Cell and T Cell Leukemias 391
7.15 Treatments for Non-Hodgkin Lymphomas 393
7.16 Treatments for Hodgkin Lymphoma and Myeloma 395
7.17 Treatments for Myeloid Cell Cancers 397
7.18 Treatments for Childhood Cancers 400
Appendix 411
Glossary of Terms 413
Index 431
| Erscheint lt. Verlag | 30.1.2025 |
|---|---|
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Gewicht | 907 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Pflege ► Fachpflege ► Onkologie | |
| ISBN-10 | 1-119-83406-6 / 1119834066 |
| ISBN-13 | 978-1-119-83406-9 / 9781119834069 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
