Altered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseases

Buch | Hardcover

438 Seiten

2024 | 2024 ed.
Springer Nature (Verlag)
978-981-97-4287-5 (ISBN)

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This book presents a systematic and extensive understanding about metabolic alterations affecting multiple aspects of different neurodegenerative diseases (NDDs), such as Alzheimer’s, Parkinson’s, Huntington’s disease, SCAs, SBMA, DRPLA, ALS, Freidrich Ataxia etc. The book also illustrates cellular and molecular mechanisms behind the key neurodegenerative diseases and further expands on concept of unique and developing biomarkers associated with the onset and progression of NDDs. Additionally, it elaborates on the concept of latest imaging tools to monitor state of NDDs and accordingly develop therapeutic approaches entailing phytochemicals in the management of metabolic alterations associated with NDDs that ultimately suppresses course of devastating NDDs. The book aids to improve the overall understanding about the NDD and involvement of metabolic disorder as a major factor for indisposition of the disease. Therefore, suggesting that targetting metabolic variations by phytochemicals can combat NDD related symptoms for the betterment of impacted patients.

While introducing cellular and molecular mechanisms and the treatment regimen under the umbrella of metabolism in several NDDs, the book covers major aspects of understanding the metabolic basis of NDDs, its implications, and treatment. This will inflate the readers' understanding about this particular area and guide those working in this domain, be it a researcher or clinicians,to choose or design effective therapeutic strategies to curb metabolic alterations linked with these disorders. This book will not only contribute towards improving the overall state of the challenged individuals but will also bring new hope towards improving the quality of lives of affected patients.

Namita Agrawal is currently a Professor at the Department of Zoology, University of Delhi, India. Prof. Agrawal has been addressing numerous questions related to debilitating neurodegenerative diseases for past 25 years. She started working on neurodegenerative diseases at the Department of Development and Cell Biology, University of California, Irvine, USA. Her research group at University of Delhi is trying to comprehend the mechanistic basis of neurodegenerative diseases and its cure by using phytochemicals. Additionally, her research interests also include understanding of various aspects involved in Cancer and nanomaterials.Prof. Agrawal has published research papers in peer-reviewed journals like Science, PNAS, Journal of Cell Biology, Development, Developmental Biology, Nature Scientific Reports, PLOS One, J. of Huntington’s disease etc. She has recently edited and wrote several chapters in a book published by Springer entitled “Toxicology of Nanoparticles: Insights from Drosophila”. Additionally, she frequently writes chapters in the books related to neurodegenerative diseases. In addition to her dedication towards research, Dr. Agrawal has almost 15 years of experience in teaching Genetics, Cytogenetics and Developmental Biology to post-graduate students at the Department of Zoology, University of Delhi, India.

Chapter 1: An Overview of Neurodegenerative Disorders.- Chapter 2: Mechanism underlying major neurodegenerative disorders.- Chapter 3: Involvement of metabolic paradigm in progression of neurodegenerative diseases.- Chapter 4: Glial cell metabolism and neurodegenerative diseases: The current perspective.- Chapter 5: Altered glucose homeostasis in neurological disorders.- Chapter 6: Lipid Metabolism: Key Determinant in Neurodegenerative Diseases.- Chapter 7 - Dysregulated peripheral metabolism in neurodegenerative disorders.- Chapter 8- Protein Metabolism: Critical factors implicated in neurodegenerative diseases.- Chapter 9 - Altered RNA metabolism in neurodegenerative disorders.- Chapter 10: Unveiling RNA dysfunction: A key player in neurodegeneration.- Chapter 11: Emerging Relationship between the Gut Microbiota and Neurodegenerative Disorders.- Chapter 12- Signaling Pathways in Neurodegenerative diseases.- Chapter 13: An overview of imaging techniques for diagnosis of debilitating neurodegenerative diseases.- Chapter 14: Novel Metabolic Biomarkers and Therapeutic Strategies in Neurodegenerative Diseases.- Chapter 15: Phytochemicals: Promising alternatives for metabolic regulation in neurodegenerative diseases.

Erscheinungsdatum	13.08.2024
Zusatzinfo	43 Illustrations, color; 17 Illustrations, black and white; XIII, 438 p. 60 illus., 43 illus. in color.
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	Alzheimer’s disease (AD) • Amyotrophic lateral sclerosis (ALS) • Biomarkers • Huntington’s disease (HD) • Imaging techniques • Lipids • Metabolic abnormalities • NDDS • Parkinson’s disease (PD) • Phytochemicals • Spinocerebellar Ataxias (SCAs) • weight loss
ISBN-10	981-97-4287-0 / 9819742870
ISBN-13	978-981-97-4287-5 / 9789819742875
Zustand	Neuware