Epigenetic Drug Discovery
Royal Society of Chemistry (Verlag)
978-1-83767-110-6 (ISBN)
Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company, and a substantial number of biotechnology companies, targeting epigenetic processes to treat diseases ranging from cancer to Huntington’s disease and from inflammation to sickle cell anaemia. This book aims to provide an overview of the key topics adopted in current epigenetic drug discovery programmes with a focus on major developments and new technologies. Importantly, the book incorporates case studies and outlines the key challenges and techniques employed to overcome them. The book is an ideal resource for researchers in both industry and academia with an interest in epigenetic and genetic factors involved in drug discovery, target ID and validation. The book is also an excellent introduction for postgraduates interested in the interface between epigenetics and pharmaceuticals.
Introduction to Drug Discovery in Epigenetics
Assay Development and Screening Strategies for Epigenetic Targets
Mass Spectrometry and Chemical Biology Approaches for Deconvoluting Epigenetic Targets
Recent Developments in the Structural Mechanism of Protein Methyltransferase Inhibition
Epigenomic Sequencing Technologies
Safety Consideration of Targeting Epigenetic Mechanisms
Toward Understanding Pharmacological Modulation of DNA Methylation and Its Effects on Gene Expression
Histone Deacetylases
Chemical Targeting of Histone Acetyltransferases
Histone Lysine Methyltransferases
Inhibiting Arginine Methylation
Histone Demethylases
Targeting the Human Acetylation Reader Family: Bromodomain Proteins
Targeting Histone Readers: Non-bromodomain Readers
Arising Opportunities and Challenges of Targeting Chromatin Remodelers
RNA Modifying Proteins: Emerging Targets for Drug Discovery
Directly Targeting RNA with Drug-like Small Molecules
Discovery and Development of Tazemetostat
Menin Inhibitors: Discovery, Development and Clinical Translation
Discovery of MTA-cooperative PRMT5 Inhibitors
| Erscheinungsdatum | 03.10.2024 |
|---|---|
| Reihe/Serie | Drug Discovery ; Volume 83 |
| Verlagsort | Cambridge |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 1194 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| ISBN-10 | 1-83767-110-9 / 1837671109 |
| ISBN-13 | 978-1-83767-110-6 / 9781837671106 |
| Zustand | Neuware |
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