Immunotherapy of Cancer

Buch | Hardcover

516 Seiten

2005
Humana Press Inc. (Verlag)
978-1-58829-564-4 (ISBN)

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Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic Approaches.- Current Strategies for the Identification of Immunogenic Epitopes of Tumor Antigens.- Current and Future Role of Natural-Killer Cells in Cancer Immunotherapy.- The Role of Immune Monitoring in Evaluating Cancer Immunotherapy.- Statistical Analysis of Immune Response Assays in Cancer Immunotherapy Trials.- DNA Vaccines for Cancer Immunotherapy.- Dendritic Cells.- Different Approaches to Dendritic Cell-Based Cancer Immunotherapy.- Anti-Idiotype Antibody Vaccines for the Immunotherapy of Cancer.- Autologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer Therapeutics.- Tumor-Reactive T-Cells for Adoptive Immunotherapy.- T-Cell Adoptive Immunotherapy of Cancer.- Retroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-Cells.- Harnessing the Potential of Graft-vs-Tumor.- Tumor-Induced Immune Suppression and Immune Escape.- The Tumor Microenvironment.- Manipulation of Lymphocyte Homeostasis for Enhancing Antitumor Immunity.- Fast-Lane Evolution in the Tumor Microenvironment.- Manipulating Immunological Checkpoints to Maximize Antitumor Immunity.- Interleukin-2 as Cancer Therapy.- Biological and Clinical Properties of the Type 1 Interferons.- Promising ?-Chain Cytokines for Cancer Immunotherapy.- The Therapeutic Use of Natural-Killer Cells in Hematological Malignancies.- Antibody Therapy for Solid Tumors.- Antibody Therapy for Non-Hodgkin’s Lymphoma.- Approaches to In Vivo Imaging of Cancer Immunotherapy.- Design Issues for Early-Stage Clinical Trials for Cancer Vaccines.- Monoclonal Antibody Therapy of Cancer.

Erscheint lt. Verlag	15.12.2005
Reihe/Serie	Cancer Drug Discovery and Development
Zusatzinfo	52 Illustrations, black and white; XII, 516 p. 52 illus.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
ISBN-10	1-58829-564-8 / 1588295648
ISBN-13	978-1-58829-564-4 / 9781588295644
Zustand	Neuware