Chiral Ligands

Evolution of Ligand Libraries for Asymmetric Catalysis

Buch | Softcover

322 Seiten

2024
CRC Press (Verlag)
978-0-367-76170-7 (ISBN)

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Many new drugs on the market are chiral compounds, that is, they can exist in two non-superimposable mirror-image forms. Asymmetric catalysis encompasses a large variety of processes for obtaining such compounds. The performance of the catalyst in those processes largely depends on the ligand that makes up the catalyst. This book describes the most relevant ligand libraries for some key processes, including an overview of the state of art and the key mechanistic aspects that favor a high catalytic performance.

Key Features:

The book presents historical content from the time of discovery for each family of ligands.
Provides a description of the synthetic route and the ligand library's application in various catalytic asymmetric reactions
Suitable as supplementary reading for courses targeting the design, synthesis and application of chiral catalysts, asymmetric catalysis and sustainable production
Edited by a distinguished scientist in the field, the book has a diverse audience including research groups in homogeneous catalysis, particularly asymmetric transformations

Montserrat Diéguez studied chemistry at the Rovira i Virgili University (URV) in Tarragona (Spain), where she earned her Ph.D. in 1997, working in the group of Prof. C. Claver. After completing a postdoctoral fellowship where she worked with Prof. R.H. Crabtree at Yale University, in New Haven (USA), she returned to Tarragona in 1999 and accepted a lectureship position at the URV, becoming part of the permanent staff in 2002. In 2011 she was promoted to full Professor in Inorganic Chemistry at the URV. She has been involved in more than 60 research projects in the fields of organometallic chemistry, steroselective synthesis, and asymmetric catalysis. She is the author/co-author of more than 150 articles in SCI-indexed journals and book chapters, and of several contributions to conferences. She received distinction from the Generalitat de Catalunya for the promotion of University Research in 2004 and from the URV in 2008. She has also been awarded the ICREA Academia Prize from the Catalan Institution for Research and Advanced Studies 2009–14 and 2015–20, for research excellence, facilitating research priority dedication. Her main research interests are focused on the sustainable design, synthesis, and screening of highly active and selective chiral catalysts for reactions of interest to the biological, pharmaceutical, and organic nanotechnological industries. Her areas of interest include organometallic chemistry, stereoselective synthesis, and asymmetric catalysis, using combinatorial and biotechnological approaches.

Contents

Preface......................................................................................................................vii

Editor.........................................................................................................................ix

List of Contributors....................................................................................................xi

Abbreviations and Acronyms................................................................................. xiii

Chapter 1 Chiral Bidentate Heterodonor P-Oxazoline Ligands ...........................1

Maria Biosca, Jordi Faiges, Montserrat Diéguez,

and Oscar Pàmies

Chapter 2 Chiral Bidentate Heterodonor P-N-Other-Ligands............................. 33

Pep Rojo, Marina Bellido, Xavier Verdaguer, and Antoni Riera

Chapter 3 Chiral Bidentate Heterodonor P,S/O Ligands..................................... 81

Jèssica Margalef and Miquel A. Pericàs

Chapter 4 Chiral Bidentate Heterodonor P-P’ ligands....................................... 109

Antonio Pizzano

Chapter 5 Chiral Tridentate-Based Ligands...................................................... 167

Uchchhal Bandyopadhyay, Basker Sundararaju, Rinaldo Poli,

and Eric Manoury

Chapter 6 Chiral N-Heterocyclic Carbene-Based Ligands................................ 195

Vincent César, Christophe Fliedel, and Agnès Labande

Chapter 7 Chiral Monophosphorus Ligands...................................................... 233

Wenjun Tang, Feng Wan, and He Yang

Chapter 8 Solvent-Oriented Ligand and Catalyst Design in Asymmetric

Catalysis – Principles and Limits ..................................................... 261

Armin Börner

Index....................................................................................................................... 315

Erscheinungsdatum	19.04.2024
Reihe/Serie	New Directions in Organic & Biological Chemistry
Zusatzinfo	362 Line drawings, black and white; 362 Illustrations, black and white
Verlagsort	London
Sprache	englisch
Maße	156 x 234 mm
Gewicht	453 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Studium ► 1. Studienabschnitt (Vorklinik)
	Naturwissenschaften ► Biologie
	Naturwissenschaften ► Chemie ► Organische Chemie
ISBN-10	0-367-76170-X / 036776170X
ISBN-13	978-0-367-76170-7 / 9780367761707
Zustand	Neuware