Pharmacology in Drug Discovery and Development

Understanding Drug Response

Terry P. Kenakin (Autor)

Buch | Softcover

444 Seiten

2024 | 3rd edition
Academic Press Inc (Verlag)
978-0-443-14124-9 (ISBN)

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Pharmacology in Drug Discovery and Development: Understanding Drug Response, Third Edition is an introductory resource that illustrates how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. The updates to the Third Edition include a new section converting “descriptive” data into “predictive” data through comparison to mathematical models, expansion on enzymes, drug metabolites and drug–drug interactions, and two new chapters. The newly developed companion website hosts further educational resources to complement the book. As in previous editions, this new edition includes numerous valuable chapter summaries, detailed references, practical examples, and case studies throughout.

Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.

1. Pharmacology: The Chemical Control of Physiology
2. Drug Affinity and Efficacy
3. Predicting Agonist Effect
4. Drug Antagonism: Orthosteric Drug Effects
5. Allosteric Drug Effects
6. Enzymes as Drug Targets
7. Pharmacokinetics I: Permeation and Metabolism
8. Pharmacokinetics II: Distribution and Multiple Dosing
9. In Vivo Pharmacology
10. Safety Pharmacology
11. The science of Finding Drug Molecules I: Validating and Screening drug targets
12. The Science of Finding Drug Molecules II: Demonstrating Target Engagement and Therapeutic Value

Erscheinungsdatum	01.06.2024
Verlagsort	San Diego
Sprache	englisch
Maße	152 x 229 mm
Gewicht	700 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
ISBN-10	0-443-14124-X / 044314124X
ISBN-13	978-0-443-14124-9 / 9780443141249
Zustand	Neuware