Radiation and Gut
Elsevier Science Ltd (Verlag)
978-0-444-89053-5 (ISBN)
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The book covers the basic structure and cell replacement process in the gut, the physical situation relevant for gut radiation exposure and a description of some of the techniques used to study radiation effects, in particular the clonal regeneration assay that assesses stem cell functional capacity. Chapters comprehensively cover the effects of radiation in experimental animal model systems and clinical experiences. The effects of radiation on the supportive tissue of the gut is also reviewed. The special radiation situation involving ingested radionuclides is reviewed and the most important late response - carcinogenesis - within the gut is considered. The volume is intended to cover the anatomy and renewal characteristics of the gut, and its response in terms of carcinogenicity and tissue injury in mammalian species including in particular man.
Part 1 Structure, function and proliferative organization of mammalian gut, C.S. Potten: introduction; BDFI ileum; BDFI large bowel; differentiation; circadian rhythms; cell hierarchies and stem cells. Part 2 Radiation sources, geometry, exposure schedules and effect quantitation for irradiation of the gut, J.H. Hendry: radiation sources; exposure geometry; exposure schedules; effect quantitation. Part 3 Clonal regeneration studies, C.S. Potten and J.H. Hendry: clonogenic cells and the microcolony assay; the number of clonogenic cells per crypt; regeneration of clonogenic cells. Part 4 Effects of radiation on murine gastrointestinal cell proliferation, C.S. Potten: introduction; induction of cell death; changes in proliferation. Part 5 Radiation effects on proliferation and differentiation in the rat small intestine, A. Becciolini et al: introduction; radiation effects; malabsorption following irradiation; the effects of ionizing radiation on gut polyamines perfusion studies; fractionated irradiation; general conclusions. Part 6 Early and late radiation effects (external radiation) on the gut, J.W. Osborne: introduction; oesophagus; stomach; small intestine; late changes in the irradiated small intestine; early and late changes in the irradiated large intestine; the gastrointestinal radiation syndrome. Part 7 Effects of irradiation on the supportive tissues of the gastrointestinal tract, B.E. Powers and E.L. Gillette: introduction; morphological changes; functional changes; pathogenesis; tolerance dose, dose fractionation and chemotherapy; conclusions. Part 8 Radiation effects on the human gastrointestinal tract, J. Barber and R.D. James: radiation effects on the gastrointestinal tract; effects of radiation on the stomach; effects of radiation upon the intestines; anus; accidental and whole body exposure - the gastrointestinal syndrome; conclusions. Part 9 Ingested radionuclides, J.D. Harrison: introduction; dosimetric models of the GI tract; gastrointestinal absorption; distribution to tissues and excretion; equivalent and effective dose; biokinetic data and doses; observed effects of ingested radionuclides; relative toxicity of radionuclides; conclusion. Part 10 Radiation carcinogenesis in the gut, J.D. Boice and R.J.M. Fry: introduction; human evidence for radiation effects; experimental animals; radiation carcinogenesis; experimental systems and the study of mechanisms; susceptibility for cancer; conclusions.
| Erscheint lt. Verlag | 22.8.1995 |
|---|---|
| Zusatzinfo | references, index |
| Verlagsort | Oxford |
| Sprache | englisch |
| Gewicht | 766 g |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie | |
| ISBN-10 | 0-444-89053-X / 044489053X |
| ISBN-13 | 978-0-444-89053-5 / 9780444890535 |
| Zustand | Neuware |
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