Respiratory Genetics

Edwin Silverman, Scott Weiss, Steven Shapiro, David Lomas (Autoren)

Buch | Hardcover

496 Seiten

2005
Hodder Arnold (Verlag)
978-0-340-81432-1 (ISBN)

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Contains a comprehensive introductory section to provide guidance and aid understanding of basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This book covers a series of disease-specific chapters that review topics such as epidemiology, natural history, and others.

There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume.

The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments.

Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.

Edwin K Silverman, Assistant Professor of Medicine, Harvard Medical School, Boston, USA Steven D Shapiro, Parker B. Francis Professor of Medicine, Harvard Medical School, Brigham & Womens Hospital, Boston, USA David A Lomas, Professor, Respiratory Medicine Unit, University of Cambridge, UK Scott T Weiss, Professor of Medicine, Harvard Medical School, Boston, USA

Part 1: Key Concepts in Respiratory Genetics
Overview of human genetics
Phenotypes for Human Respiratory Genetics
Testing for association in genetic studies
Sample Collection and Genotyping for Human Respiratory Genetics
Molecular characterization of genetic variation: sample collection and processing in human respiratory genetics
Molecular characterization of genetic variation: genetic variation, genotyping, and sequencing
Bioinformatics: public databases and SNPs
Bioinformatics: genomics and proteomics in lung disease: microarrays and bioinformatics issues
Functional genomics: clinical functional genomics
Functional genomics: expression and purification of recombinant proteins
Functional genomics: functional characterization of a protein
Functional genomics: biophysical analysis of proteins and proteinâ€“protein interactions
Functional genomics: crystallography, nuclear magnetic resonance, and modeling
Functional genomics: functional analysis of mutant proteins in cells
Genomic physiology in animals
Pharmacogenetics
Part 2: Obstructive lung diseases
Asthma genetics
Chronic obstructive pulmonary disease
Cystic fibrosis
Part 3: Interstitial lung diseases
Idiopathic pulmonary fibrosis
Sarcoidosis
Part 4: Miscellaneous pulmonary conditions
Pulmonary hypertension
Genetics of lung cancer
Respiratory infections
Congenital, metabolic, and neuromuscular diseases
Other rare lung diseases: disorders of surfactant homeostasis
Other rare lung diseases: lymphangioleiomyomatosis
Other rare lung diseases: Hermanskyâ€“Pudlak Syndrome

Erscheint lt. Verlag	30.9.2005
Zusatzinfo	150 b/w line drawings, 50 b/w halftones, 20 colour halftones
Verlagsort	London
Sprache	englisch
Maße	210 x 276 mm
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
	Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
ISBN-10	0-340-81432-2 / 0340814322
ISBN-13	978-0-340-81432-1 / 9780340814321
Zustand	Neuware